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Original Article
- Thoracic surgery
- Perfusion parameters during cardiopulmonary bypass as a predictor of acute kidney injury after aortic valve replacement
- Yeiwon Lee, Sue Hyun Kim, Ho Young Hwang, Suk Ho Sohn, Jae Woong Choi, Kyung Hwan Kim
- Acute Crit Care. 2021;36(3):242-248. Published online August 12, 2021
- DOI: https://doi.org/10.4266/acc.2021.00094
- 10,633 View
- 199 Download
- 3 Web of Science
- 3 Crossref
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Abstract
PDF - Background
Acute kidney injury (AKI) is a major complication after cardiac surgery and significantly affects postoperative mortality and morbidity. This study was conducted to evaluate the association between target pump flow to achieve adequate oxygen delivery (DO2) and postoperative renal function after aortic valve replacement.
Methods
From January 2017 to May 2020, 281 patients (male:female, 160:121; mean age, 68±11 years) who underwent aortic valve replacement were retrospectively reviewed. Target pump flow was calculated based on DO2 level of 280 mL/min/m2. The primary endpoint was postoperative renal dysfunction, defined as the ratio of postoperative peak creatinine level to preoperative value. The ratio of the lowest actual pump flow to the ideal target pump flow, other hemodynamic variables related with cardiopulmonary bypass, intraoperative transfusion, and preoperative characteristics were analyzed to identify factors associated with the primary endpoint using a multivariable linear regression model.
Results
Preoperative and peak postoperative creatinine levels were 0.94±0.33 mg/dl and 1.15±0.56 mg/dl, respectively (ratio, 1.22±0.33). The ideal target pump flow was 4.70±0.59 L/min, whereas the lowest actual pump flow was 3.77±0.47 L/min (ratio, 0.81±0.13). The multivariable model showed that the ratio of the lowest pump flow to target pump flow (β±standard error, –0.405±0.162, P=0.013), as well as sex, stroke history, emergency operation, and transfusion of red blood cells were associated with the primary endpoint.
Conclusions
Low actual nadir pump flow compared to the ideal target pump flow based on DO2 is associated with the risk of AKI after aortic valve replacement. -
Citations
Citations to this article as recorded by
- Perioperative hyperoxia versus normoxia during cardiopulmonary bypass in adult cardiac surgery: a systematic review and meta-analysis of randomized controlled trials
Najat Y. AlSejari, Batoul H. Aljaber, Saud A. Alyahya, Abdullah M. Alharran, Hamza A. Abdul-Hafez, Amal A. Alsubaiei
Journal of Cardiothoracic Surgery.2026;[Epub] CrossRef - Predictors for and Consequences of Acute Kidney Injury After Surgical Aortic Valve Replacement: An Observational Retrospective Study
Ivo Deblier, Karl Dossche, Anthony Vanermen, Wilhelm Mistiaen
Journal of Clinical Medicine.2025; 14(20): 7159. CrossRef - Alterations to Kidney Physiology during Cardiopulmonary Bypass—A Narrative Review of the Literature and Practical Remarks
Jakub Udzik, Jerzy Pacholewicz, Andrzej Biskupski, Paweł Walerowicz, Kornelia Januszkiewicz, Ewa Kwiatkowska
Journal of Clinical Medicine.2023; 12(21): 6894. CrossRef
- Perioperative hyperoxia versus normoxia during cardiopulmonary bypass in adult cardiac surgery: a systematic review and meta-analysis of randomized controlled trials
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