KSCCM
Search
- Page Path
- HOME > Search
Original Article
- Infection
- Sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsis
- Balaram Krishna J Hanumanthu, Anika Sasidharan Nair, Adarsh Katamreddy, Jason S Gilbert, Jee Young You, Obiageli Lynda Offor, Ankit Kushwaha, Ankita Krishnan, Marzio Napolitano, Leonidas Palaidimos, Joaquin Morante, Seema S. Tekwani, Suchita Mehta, Aanchal Gupta, Harmeen Goraya, Mengyang Sun, Robert T. Faillace, Perminder Gulani
- Acute Crit Care. 2021;36(3):215-222. Published online July 26, 2021
- DOI: https://doi.org/10.4266/acc.2021.00234
- 14,239 View
- 295 Download
- 41 Web of Science
- 44 Crossref
-
Abstract
PDF - Background
Patients with sepsis are at risk for developing sepsis-induced cardiomyopathy (SIC). Previous studies offer inconsistent results regarding the association of SIC and mortality. This study sought to assess whether SIC is linked to mortality in patients with sepsis and to evaluate predictors of the development of SIC.
Methods
In this retrospective study, patients admitted to the medical intensive care unit with a diagnosis of sepsis in the absence of acute coronary syndrome were included. SIC was identified using transthoracic echo and was defined by a new onset decline in left ventricular ejection fraction (LVEF) ≤50%, or ≥10% decline in LVEF compared to baseline in patients with a history of heart failure with reduced ejection fraction. Multivariable logistic regression analysis was performed using the R software program.
Results
Of the 359 patients in the final analysis, 19 (5.3%) had SIC. Eight (42.1%) of the 19 patients in the SIC group and 60 (17.6%) of the 340 patients in the non-SIC group died during hospitalization. SIC was associated with an increased risk for all-cause in-hospital mortality (odds ratio [OR], 4.46; 95% confidence interval [CI], 1.15–18.69; P=0.03). Independent predictors for the development of SIC were albumin level (OR, 0.47; 95% CI, 0.23–0.93; P=0.03) and culture positivity (OR, 8.47; 95% CI, 2.24–55.61; P=0.006). Concomitant right ventricular hypokinesis was noted in 13 (68.4%) of the 19 SIC patients.
Conclusions
SIC was associated with an increased risk for all-cause in-hospital mortality. Low albumin level and culture positivity were independent predictors of SIC. -
Citations
Citations to this article as recorded by
- Current challenges in understanding, diagnosing and managing sepsis-induced cardiac dysfunction
Catalina Paraschiv, Mihaela Roxana Popescu Moraru, Livia Florentina Paduraru, Claudia Andreea Palcau, Andreea Catarina Popescu, Serban Mihai Balanescu
Journal of Critical Care.2026; 91: 155250. CrossRef - Acute left ventricular ejection fraction changes in Sepsis: Clinical predictors, management, and hospital outcomes
Mohamad Ghazal, Shayhaan Shaikh, Zachary Daniel, Omar Daghstani, John Musumeci, Abhinay Gajjala, Scott H. Beegle, Mikhail Torosoff
Heart & Lung.2026; 75: 225. CrossRef - Nsun2-mediated m5C methylation of Ncor1 exacerbates sepsis-induced cardiomyopathy by promoting mitochondrial dysfunction
Chan Chen, Qing Liu, Junmei Xu, Mengyuan Zi, Xinglan Chen, Feng Xiao
Free Radical Biology and Medicine.2026; 246: 17. CrossRef - LINC00963 targeting miR-98-5p exacerbates sepsis-induced myocardial injury
Yanling Chen, Xinming Li, Xiemuziya Maimaitirexiati, Chan Li, Huijing Zhao, Zhenling Gao
Internal and Emergency Medicine.2026; 21(3): 877. CrossRef - Incidence and Prognostic Impact of Myocardial Dysfunction in Septic Shock: An Observational Cohort Study
Zahid M Nadaf, Rajathadri H Ravikumar, Rahul K Anand, Rashmi Ramachandran, Anjan Trikha, Naveet Wig, Vimi Rewari
Indian Journal of Critical Care Medicine.2026; 30(1): 56. CrossRef - Sepsis-induced cardiomyopathy: mechanisms, epidemiology, diagnosis, and treatments
Fei Cao, Tao Yan, Chaoyue Liang, Ao Liu, Junyan Wang
Frontiers in Immunology.2026;[Epub] CrossRef - Quantitative assessment and prognostic value of myocardial work indices in sepsis-induced cardiomyopathy patients with left ventricular systolic dysfunction
Xu Yanping, Yang Xiaojuan, Wu Jiali, Yang Xue, Pan Lu, Wang Xiaohong, Yang Ying, Wang Ying, Cao Wei, Na Lisha
Cardiovascular Ultrasound.2026;[Epub] CrossRef - Macrophage C3aR1 Mediates Sepsis‐Induced Myocardial Injury by Triggering Neutrophil Necroptosis
Jianbo Xu, Zhilei He, Rubing Zhang, Chaonan Peng, Ziteng Cai, Xinyue Zhao, Weiqun Wang
Journal of Cellular and Molecular Medicine.2026;[Epub] CrossRef - Regulation of mitochondrial fission by Drp1 in cardiomyopathy: possible mechanisms linking cellular processes to cell death
Nandini Dubey, Pranav Panchbhai, Gauri Chaturvedi, Satnam Singh, Ahsas Goyal, Neeraj Parakh, Rajiv Narang, Sudhir Kumar Arava, Arvind Kumar, Mayank Yadav, Harlokesh Narayan Yadav
Molecular Biology Reports.2026;[Epub] CrossRef - CEBPD-MMP8 Axis Contributes to Cardiomyocyte Injury in Septic Shock
Yang Yu, Decui Pei, Jia Liu, Keming Chen, Wenjing Zhang, Heying Zhong
Applied Biochemistry and Biotechnology.2026;[Epub] CrossRef - Decreased Left Ventricular Ejection Fraction is Associated with Increased Mortality in Sepsis: A Retrospective Cohort Study
August A. Longino, Jacqueline A. Urban, Katharine C. Martin, Katarina R. Leyba, Theresa N. Thai, Ivor S. Douglas, David S. Raymer
European Journal of Heart Failure.2025; 27(1): 174. CrossRef - Septic Cardiomyopathy: Difficult Definition, Challenging Diagnosis, Unclear Treatment
George E. Zakynthinos, Grigorios Giamouzis, Andrew Xanthopoulos, Evangelos Oikonomou, Konstantinos Kalogeras, Nikitas Karavidas, Ilias E. Dimeas, Ioannis Gialamas, Maria Ioanna Gounaridi, Gerasimos Siasos, Manolis Vavuranakis, Epaminondas Zakynthinos, Vas
Journal of Clinical Medicine.2025; 14(3): 986. CrossRef - Neutrophil-derived exosomal S100A8 aggravates lung injury in sepsis by inducing pyroptosis
Xinxin Li, Wei Zhou, Liangliang Zhou, Yingbin Li, Xufeng Wu, Jianjun Chen
Molecular Immunology.2025; 181: 29. CrossRef - Interaction between post-tumor inflammation and vascular smooth muscle cell dysfunction in sepsis-induced cardiomyopathy
Rui Liu, Lina Jia, Lin Yu, Detian Lai, Qingzhu Li, Bingyu Zhang, Enwei Guo, Kailiang Xu, Qiancheng Luo
Frontiers in Immunology.2025;[Epub] CrossRef - Investigating the Mechanism of Cinnamon Twig Decoction without Peony Combined with Ephedra and Aconite and Asarum Decoction in Treating SIMD Based on Network Pharmacology and Molecular Docking
凌萱 张
Journal of Clinical Personalized Medicine.2025; 04(02): 1232. CrossRef - Xuebijing Exerts Protective Effects on Myocardial Cells by Upregulating TRIM16 and Inhibiting Oxidative Stress and Apoptosis
Xiaoyan Meng, Xinming Yan, Peng Xue, Zhaoqing Xi
Current Computer-Aided Drug Design.2025; 21(4): 503. CrossRef - Diagnostic Utility of Pentraxin 3 Expression in Septic Cardiomyopathy: Findings from a Prospective Observational Study
Na Cui, Xiao-Wei Lv, Teng-Hao Shao, Zhan-Biao Yu, Zhi Chen, Tao Sun, Tie-Min Li, Jin-Wen Zhang, Zhen-Jie Hu
Journal of Inflammation Research.2025; Volume 18: 6025. CrossRef - Predicting prognosis of sepsis in patients based on right ventricular strain imaging development and validation of a nomogram model
Qinxin Wang, Hongmin Chen, Bingyi Zhang, Chang Zhou, Boyuan Xing, Chang Li, Shijin Xu, Yun Liu
Frontiers in Cardiovascular Medicine.2025;[Epub] CrossRef - Three-dimensional (3D) vs. conventional echo evaluation of ventricular function in patients with sepsis or septic shock: a prognostic value
Abdelrahman K. Mohamed, Shereen M. El Gengeehy, Ahmed Abdelrahman Battah, Mohamed Hamdi Saleh, Soliman Belal
The Egyptian Journal of Critical Care Medicine.2025;[Epub] CrossRef - Time Course of Morbidity and Mortality Across Echocardiographic Phenotypes in Patients With Sepsis: A Systematic Review and Meta-Analysis
Jie Wang, Zewen Tong, Xiaoting Wang, Guangjian Wang
Critical Care Medicine.2025; 53(11): e2294. CrossRef - Laboratory and Microbiological Considerations in Sepsis-Induced Cardiac Dysfunction
Catalina Paraschiv, Denisa Oana Nicolaescu, Mihaela Roxana Popescu, Carmen Cristina Vasile, Emanuel Moisa, Silvius Ioan Negoita, Serban Mihai Balanescu
Medicina.2025; 61(10): 1765. CrossRef - NT-proBNP, Echocardiography Patterns and Outcomes in Sepsis-Induced Cardiac Dysfunction
Catalina Paraschiv, Denisa Oana Nicolaescu, Roxana Mihaela Popescu, Laura Barbalata, Emanuel Moisa, Silvius Negoita, Andreea Catarina Popescu, Serban Mihai Balanescu
Journal of Clinical Medicine.2025; 14(24): 8714. CrossRef - Construction and Validation of a Risk Prediction Model for Sepsis-Induced Myocardial Injury
Yi Gou, Yun Cong, Zhen-Zhen Guo, Ailikuti Aikepaer, Wen-Ting Jia, Si-Bo Liu, Ya-Ge Chai, Dan-Dan Li, Jian-Zhong Yang
International Journal of General Medicine.2025; Volume 18: 7579. CrossRef - Inhibition of Pyruvate Dehydrogenase Kinase 4 Attenuates Myocardial and Mitochondrial Injury in Sepsis-Induced Cardiomyopathy
Tangtian Chen, Liang Ye, Jing Zhu, Bin Tan, Qin Yi, Yanting Sun, Qiumin Xie, Han Xiang, Rui Wang, Jie Tian, Hao Xu
The Journal of Infectious Diseases.2024; 229(4): 1178. CrossRef - Meta-Analysis of Initial Natriuretic Peptides in the Setting of Sepsis-Induced Myocardial Dysfunction
Boyong He, Xin Wang, Liguo Shi, Hongbin Cheng, Luyi Zhao
Biomarkers in Medicine.2024; 18(4): 145. CrossRef - Examining the relationship between alterations in plasma cholesterol, vascular endothelin-1 levels, and the severity of sepsis in children: An observational study
Jing Xu, Wenli Shen, Xiaotao Zhang, Hongli Zhu, Yunduo Wu, Qizheng Wang, Changqiang Cui, Li Zha, Yan Jiao Lu, Rui Liu, Xiaofei Lin
Medicine.2024; 103(28): e38348. CrossRef - The Usefulness of Strain Echocardiography as Diagnostic and Prognostic Index of Cardiac Dysfunction in Septic Patients in Correlation with Cardiac Biomarkers
Mostafa El Mokadem, Sameh El Maraghi, Rania El Hosseiny, Amr Moawad, Ahmed Yassin
Journal of Cardiovascular Echography.2024; 34(3): 114. CrossRef - Immune-response gene 1 deficiency aggravates inflammation-triggered cardiac dysfunction by inducing M1 macrophage polarization and aggravating Ly6Chigh monocyte recruitment
Song Shen, Jianhui Li, Zhonghai Wei, Yihai Liu, Lina Kang, Rong Gu, Xuan Sun, Biao Xu, QiaoLing Li
Biology Direct.2024;[Epub] CrossRef - Early management of adult sepsis and septic shock: Korean clinical practice guidelines
Chul Park, Nam Su Ku, Dae Won Park, Joo Hyun Park, Tae Sun Ha, Do Wan Kim, So Young Park, Youjin Chang, Kwang Wook Jo, Moon Seong Baek, Yijun Seo, Tae Gun Shin, Gina Yu, Jongmin Lee, Yong Jun Choi, Ji Young Jang, Yun Tae Jung, Inseok Jeong, Hwa Jin Cho, A
Acute and Critical Care.2024; 39(4): 445. CrossRef - The Complexities of Sepsis-Induced Cardiomyopathy: A Clinical Case and Review of Inflammatory Pathways and Potential Therapeutic Targets
Pawel Borkowski, Michal Borkowski, Natalia Borkowska, Vishakha Modak, Natalia Nazarenko, Shaunak Mangeshkar, Anita Osabutey, Maisha Maliha, Ishmum Chowdhury, Ashot Batikyan, Bisrat Adal, Vikyath Satish
Cureus.2024;[Epub] CrossRef - Therapeutic Dilemmas in Mixed Septic-Cardiogenic Shock
Daniela Urina Jassir, Antoine H. Chaanine, Sapna Desai, Indranee Rajapreyar, Thierry H. Le Jemtel
The American Journal of Medicine.2023; 136(1): 27. CrossRef - A case of sepsis‐induced cardiomyopathy successfully treated with venoarterial extracorporeal membrane oxygenation
Keigo Sato, Akihiro Naito, Taichi Shiratori, Masahiro Yamamoto, Kenichi Shimane, Manabu Mikami, Mariko Senda, Haruki Kume, Motofumi Suzuki
IJU Case Reports.2023; 6(1): 26. CrossRef - RNF20 deletion causes inflammation in model of sepsis through the NLRP3 activation
Anlong Qi, Yancun Liu, Jianhua Zhai, Yongtao Wang, Wang Li, Tong Wang, Yanfen Chai
Immunopharmacology and Immunotoxicology.2023; 45(4): 469. CrossRef - S100a8/a9 contributes to sepsis-induced cardiomyopathy by activating ERK1/2-Drp1-mediated mitochondrial fission and respiratory dysfunction
Feng Wu, Yan-Ting Zhang, Fei Teng, Hui-Hua Li, Shu-Bin Guo
International Immunopharmacology.2023; 115: 109716. CrossRef - Ultrasound in Sepsis and Septic Shock—From Diagnosis to Treatment
Gianluca Tullo, Marcello Candelli, Irene Gasparrini, Sara Micci, Francesco Franceschi
Journal of Clinical Medicine.2023; 12(3): 1185. CrossRef - A novel signature combing cuproptosis- and ferroptosis-related genes in sepsis-induced cardiomyopathy
Juanjuan Song, Kairui Ren, Dexin Zhang, Xinpeng Lv, Lin Sun, Ying Deng, Huadong Zhu
Frontiers in Genetics.2023;[Epub] CrossRef - Prevalence and Prognosis of Sepsis-Induced Cardiomyopathy: A Systematic Review and Meta-Analysis
Daisuke Hasegawa, Yoshiko Ishisaka, Tetsuro Maeda, Narut Prasitlumkum, Kazuki Nishida, Siddharth Dugar, Ryota Sato
Journal of Intensive Care Medicine.2023; 38(9): 797. CrossRef - Sepsis-Induced myocardial dysfunction: heterogeneity of functional effects and clinical significance
Tatyana Shvilkina, Nathan Shapiro
Frontiers in Cardiovascular Medicine.2023;[Epub] CrossRef - Research Progress on the Mechanism and Management of Septic Cardiomyopathy: A Comprehensive Review
Xue-Bin Pei, Bo Liu, Maciej Dyrbuś
Emergency Medicine International.2023; 2023: 1. CrossRef - Protein Phosphatase 2A Improves Cardiac Functional Response to Ischemia and Sepsis
Ulrich Gergs, Tina Jahn, Nico Schulz, Claudia Großmann, Uwe Rueckschloss, Uta Demus, Igor B. Buchwalow, Joachim Neumann
International Journal of Molecular Sciences.2022; 23(9): 4688. CrossRef - Feasibility and discriminatory value of tissue motion annular displacement in sepsis-induced cardiomyopathy: a single-center retrospective observational study
Jieqiong Song, Yao Yao, Shilong Lin, Yizhou He, Duming Zhu, Ming Zhong
Critical Care.2022;[Epub] CrossRef - Sepsis-Induced Cardiomyopathy Reviewed: The Case for Early Consideration of Mechanical Support
Daniel L. Plack, Olivier Royer, Etienne J. Couture, Christoph G.S. Nabzdyk
Journal of Cardiothoracic and Vascular Anesthesia.2022; 36(10): 3916. CrossRef - Association of sepsis-induced cardiomyopathy and mortality: a systematic review and meta-analysis
Yu-Min Lin, Mei-Chuan Lee, Han Siong Toh, Wei-Ting Chang, Sih-Yao Chen, Fang-Hsiu Kuo, Hsin-Ju Tang, Yi-Ming Hua, Dongmei Wei, Jesus Melgarejo, Zhen-Yu Zhang, Chia-Te Liao
Annals of Intensive Care.2022; 12(1): 112. CrossRef - Association of Sepsis-Induced Cardiomyopathy and Mortality: A Systematic Review and Meta-Analysis
Yu-Min Lin, Mei-Chuan Lee, Han Siong Toh, Wei-Ting Chang, Sih-Yao Chen, Fang-Hsiu Kuo, Hsin-Ju Tang, Yi-Ming Hua, Dongmei Wei, Jesus Melgarejo, Zhen-Yu Zhang, Chia-Te Liao
SSRN Electronic Journal .2022;[Epub] CrossRef
- Current challenges in understanding, diagnosing and managing sepsis-induced cardiac dysfunction
First
Prev
