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2 "Suk Ho Sohn"
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Original Articles
Meta-analysis
Impact of perioperative high-intensity statin treatment on the occurrence of postoperative atrial fibrillation after coronary artery bypass grafting: a meta-analysis
Yeiwon Lee, Somin Im, Yoonjin Kang, Suk Ho Sohn, Myoung-jin Jang, Ho Young Hwang
Acute Crit Care. 2024;39(4):507-516.   Published online November 25, 2024
DOI: https://doi.org/10.4266/acc.2024.00633
  • 8,172 View
  • 219 Download
  • 5 Web of Science
  • 4 Crossref
AbstractAbstract PDF
Background
This meta-analysis was conducted to evaluate the impact of high-intensity statin treatment on new-onset postoperative atrial fibrillation (POAF) after coronary artery bypass grafting (CABG).
Methods
Four databases were searched for studies that enrolled patients who underwent CABG and investigated the impact of perioperative use of high-intensity statins on the occurrence rate of POAF. The primary outcome was the incidence of POAF. Secondary outcomes were operative mortality and perioperative myocardial infarction (PMI). Publication bias was assessed using a funnel plot and Egger’s test.
Results
Nine articles (eight randomized controlled trials and one non-randomized study: n=3,072) were selected. Rosuvastatin (20 mg) was used in four studies, while atorvastatin (40–80 mg) was used in the other five studies. Reported incidences of POAF in the included studies ranged from 11% to 48.8%. Pooled analyses showed that the incidence of POAF was significantly lower in patients treated with high-intensity statins than in patients in the control group patients (odds ratio, 0.43; 95% CI, 0.27–0.68; P<0.001). Subgroup analyses showed that the impact of high-intensity statins was significant in studies using atorvastatin but not in studies using rosuvastatin. There was no significant subgroup difference in the primary endpoint between studies using a placebo and those using low-dose statins. Secondary outcomes, including operative mortality and the incidence of PMI, were not affected by high-intensity statin treatment.
Conclusions
Perioperative use of high-intensity statins is associated with a 57% reduction in the occurrence of POAF among patients undergoing CABG.

Citations

Citations to this article as recorded by  
  • Comparative Effects of Different Statin Regimens on Postoperative Outcomes in Isolated Coronary Artery Bypass Grafting: A Propensity Score-Matched Analysis
    Osman Fehmi Beyazal, Zeki Temizturk, Cemalettin Aydin, Mehmet Okan Donbaloglu, Arjen Erdal, Selman Sadi Citak, Nihan Kayalar, Mehmed Yanartas
    Journal of Clinical Medicine.2026; 15(15): 6060.     CrossRef
  • Cardiac Surgery 2024 Reviewed
    Hristo Kirov, Tulio Caldonazo, Murat Mukharyamov, Sultonbek Toshmatov, Philine Fleckenstein, Timur Kyashif, Thierry Siemeni, Torsten Doenst
    The Thoracic and Cardiovascular Surgeon.2025; 73(05): 332.     CrossRef
  • Impact of statin treatment on postoperative atrial fibrillation in surgical aortic valve replacement
    Lytfi Krasniqi, Joachim Sejr Skovbo, Jesper Hallas, Axel Brandes, Poul Erik Mortensen, Oke Gerke, Emil Johannes Ravn, Viktor Poulsen, Ivy Susanne Modrau, Katrine M. Müllertz, Jordi Sanchez Dahl, Lars Peter Riber
    American Heart Journal.2025; 290: 82.     CrossRef
  • Koronarchirurgie – Literaturübersicht 2024
    Philine Fleckenstein, Tulio Caldonazo, Murat Mukharyamov, Sultonbek Toshmatov, Timur Kyashif, Thierry Siemeni, Torsten Doenst, Hristo Kirov
    Zeitschrift für Herz-,Thorax- und Gefäßchirurgie.2025; 39(6): 362.     CrossRef
Thoracic surgery
Perfusion parameters during cardiopulmonary bypass as a predictor of acute kidney injury after aortic valve replacement
Yeiwon Lee, Sue Hyun Kim, Ho Young Hwang, Suk Ho Sohn, Jae Woong Choi, Kyung Hwan Kim
Acute Crit Care. 2021;36(3):242-248.   Published online August 12, 2021
DOI: https://doi.org/10.4266/acc.2021.00094
  • 10,624 View
  • 199 Download
  • 3 Web of Science
  • 3 Crossref
AbstractAbstract PDF
Background
Acute kidney injury (AKI) is a major complication after cardiac surgery and significantly affects postoperative mortality and morbidity. This study was conducted to evaluate the association between target pump flow to achieve adequate oxygen delivery (DO2) and postoperative renal function after aortic valve replacement.
Methods
From January 2017 to May 2020, 281 patients (male:female, 160:121; mean age, 68±11 years) who underwent aortic valve replacement were retrospectively reviewed. Target pump flow was calculated based on DO2 level of 280 mL/min/m2. The primary endpoint was postoperative renal dysfunction, defined as the ratio of postoperative peak creatinine level to preoperative value. The ratio of the lowest actual pump flow to the ideal target pump flow, other hemodynamic variables related with cardiopulmonary bypass, intraoperative transfusion, and preoperative characteristics were analyzed to identify factors associated with the primary endpoint using a multivariable linear regression model.
Results
Preoperative and peak postoperative creatinine levels were 0.94±0.33 mg/dl and 1.15±0.56 mg/dl, respectively (ratio, 1.22±0.33). The ideal target pump flow was 4.70±0.59 L/min, whereas the lowest actual pump flow was 3.77±0.47 L/min (ratio, 0.81±0.13). The multivariable model showed that the ratio of the lowest pump flow to target pump flow (β±standard error, –0.405±0.162, P=0.013), as well as sex, stroke history, emergency operation, and transfusion of red blood cells were associated with the primary endpoint.
Conclusions
Low actual nadir pump flow compared to the ideal target pump flow based on DO2 is associated with the risk of AKI after aortic valve replacement.

Citations

Citations to this article as recorded by  
  • Perioperative hyperoxia versus normoxia during cardiopulmonary bypass in adult cardiac surgery: a systematic review and meta-analysis of randomized controlled trials
    Najat Y. AlSejari, Batoul H. Aljaber, Saud A. Alyahya, Abdullah M. Alharran, Hamza A. Abdul-Hafez, Amal A. Alsubaiei
    Journal of Cardiothoracic Surgery.2026;[Epub]     CrossRef
  • Predictors for and Consequences of Acute Kidney Injury After Surgical Aortic Valve Replacement: An Observational Retrospective Study
    Ivo Deblier, Karl Dossche, Anthony Vanermen, Wilhelm Mistiaen
    Journal of Clinical Medicine.2025; 14(20): 7159.     CrossRef
  • Alterations to Kidney Physiology during Cardiopulmonary Bypass—A Narrative Review of the Literature and Practical Remarks
    Jakub Udzik, Jerzy Pacholewicz, Andrzej Biskupski, Paweł Walerowicz, Kornelia Januszkiewicz, Ewa Kwiatkowska
    Journal of Clinical Medicine.2023; 12(21): 6894.     CrossRef
ACC : Acute and Critical Care
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