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Case Report
- Multiple Organ Dysfunction Syndrome and Quadriplegia due to Acute Methamphetamine Intoxication: A Case Report
- Oh Young Kwon, Jong Seok Lee, Han Sung Choi, Hoon Pyo Hong, Young Gwan Ko
- Korean J Crit Care Med. 2010;25(1):33-36.
- DOI: https://doi.org/10.4266/kjccm.2010.25.1.33
- 2,564 View
- 18 Download
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Abstract
PDF - Methamphetamine (MA) is an extremely addictive central nervous system stimulant. MA abuse has increased during the past three decades in Korea because it is cheap relatively and easily produced. Acute toxicity can occur via nasal insufflation, intravenous administration and ingestion of liquid formulations. The clinical manifestations include hypertension, tachycardia, hyperthermia, an altered mentality and seizure. Severe complications can occur such as pulmonary edema, rhabdomyolysis, disseminated intravascular coagulation and multiple organ dysfunction syndrome. This case report describes a previously healthy 40-year-old woman who presented to an emergency department with complaints of hyperthermia, an altered mentality and vomiting. This patient was diagnosed as acute MA intoxication by urine toxicology screening, and she showed a variety of clinical manifestations and complications. Physicians should suspect MA intoxication if a patient shows an unknown fever, an altered mentality and hypertension, and they should carefully manage these patients in the ICU.
Review
- Inflammation and Sepsis
- Ji Young Yoon, Jae Young Kwon
- Korean J Crit Care Med. 2010;25(1):1-8.
- DOI: https://doi.org/10.4266/kjccm.2010.25.1.1
- 3,131 View
- 88 Download
- 7 Crossref
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Abstract
PDF
- Despite the development of modern intensive care and new antimicrobial agents, the mortality of the patients with severe sepsis and septic shock remains high. The poor outcome is considered to be a consequence of an overactive systemic inflammatory response. Sepsis is now defined as systemic inflammatory response syndrome (SIRS) in which there is an identifiable focus of infection. As a consequence of the overactive SIRS response, the function of various organ systems may be compromised, resulting in multiple organ dysfunction syndrome (MODS) and death. Systemic inflammation is a consequence of activation of the innate immune system. It is characterized by intravascular release of pro-inflammatory cytokines and other vasoactive mediators, and the concurrent activation of the innate immune cells. In addition to the pro-inflammatory reactions, the host's anti-inflammatory mechanisms are also activated and aimed at counteracting the inflammatory response. The balance between pro- and anti-inflammatory reactions is critical for the outcome of the patient. Understanding the mechanisms of acute inflammatory responses in critical ill patients is necessary for the development of urgently needed therapeutics. The aim of this review is to provide a description of the key components and mechanisms involved in the inflammatory response in patients with SIRS and sepsis.
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Citations
Citations to this article as recorded by
- A Study on the Relationship Between Sayeok-tang and Systemic Inflammatory Response Syndrome
Ju-Hyun Lee, Sang-Bae Lee, Eun-Heui Jo, Min-Cheol Park
Journal of Korean Medicine.2024; 45(2): 1. CrossRef - Enhancing acute inflammatory and sepsis treatment: superiority of membrane receptor blockade
Seok-Jun Mun, Euni Cho, Hyo Keun Kim, Woo Jin Gil, Chul-Su Yang
Frontiers in Immunology.2024;[Epub] CrossRef - A Study on the Relationship Between Daeseunggi-tang and Sepsis
Ju-Hyun Lee, Eun-Heui Jo, Min-Cheol Park
Journal of Korean Medicine.2023; 44(3): 39. CrossRef - Risk Factors for Unawareness of Obstructive Airflow Limitation among Adults with Chronic Obstructive Pulmonary Disease
Mirae Jo, Heeyoung Oh
Journal of Korean Academy of Community Health Nursing.2018; 29(3): 290. CrossRef - The Anti-Inflammatory Effect of Arginine-Vasopressin on Lipopolysaccharide-Induced IκBα/Nuclear Factor-κB Cascade
Jisoo Park, Eun Young Eo, Kyoung-Hee Lee, Jong Sun Park, Jae-Ho Lee, Chul-Gyu Yoo, Choon-Taek Lee, Young-Jae Cho
The Korean Journal of Critical Care Medicine.2015; 30(3): 151. CrossRef - Splenic Hemorrhage with Hemoperitoneum Caused by a Snakebite
Ji Young Yhi, Yoomi Yeo, Ji Yeoun Kim, Il Hwan Oh, Soon Woo Hwang, Sang Ki Lee, Dong Shin Kwak, Ji-Yoon Choi, Jeong Eun Kim, Joon-Sung Park
Korean Journal of Critical Care Medicine.2013; 28(4): 336. CrossRef - A Case of Systemic Inflammatory Response Syndrome Secondary to an Acute Polyarticular Gout
Ji Hyun Cheon M.D., Ji Ung Kim M.D., Sun Kwang Kim M.D., Sung Hyun Ko M.D., Jun Ho Jo M.D., Geon Woo Park M.D., Jin Suk Lee M.D., Hyoung Yoel Park M.D.
Journal of the Korean Geriatrics Society.2012; 16(3): 158. CrossRef
- A Study on the Relationship Between Sayeok-tang and Systemic Inflammatory Response Syndrome
Original Article
- The Effect of Discharge Decision-Making of the Intensivist on Readmission to the Intensive Care Unit
- Dong Woo Han, One Chul Kang, So Young Ban, Shin Ok Koh
- Korean J Crit Care Med. 2003;18(2):74-79.
- 1,651 View
- 18 Download
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Abstract
PDF
- BACKGROUND
Patients readmitted to intensive care unit (ICU) have significantly higher mortality. The role of intensivists to judge when to discharge from ICU may be important. We performed this study to assess the effect of intensivist's discharge decision-making on readmission to ICU. METHODS: Data were collected prospectively from patients admitted to ICUs (group 1). Another data were collected retrospectively from the patients' record (group 2). Discharge of the patients in group 1 were based on intensivist's discharge decision-making but not in group 2. We encouraged deep breathing and expectoration to patients of group 1 at risk of pulmonary complication during ICU stay and used a guideline for making discharge decisions. Readmission cause, length of ICU stay, Acute Physiology and Chronic Health Evaluation (APACHE) III score, and multiple organ dysfunction syndrome (MODS) score of readmitted patients were evaluated. RESULTS: Readmission rate of group 1 was lower than that of group 2 (p<0.05). The mortality of readmitted patients in each group was higher than that of non-readmitted patients (p<0.05). Respiratory disease was the major cause of readmission. In non-survivors of readmitted patients, APACHE III score on initial discharge and readmission, MODS score on initial admission, discharge and readmission were higher than those of survivors (p<0.05). CONCLUSIONS: Readmission rate was lower when intensivists participated in discharge decision- making. ICU readmission was associated with higher hospital mortality and longer ICU stay. MODS and APACHE III score at first discharge and readmission were significant prognostic factors of the outcome in readmitted patients.
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