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Case Report
A Critical Case of Wernicke's Encephalopathy Induced by Hyperemesis Gravidarum
Byung Ju Kang, Min Gu Kim, Jwa Hoon Kim, Mingee Lee, Sang-Beom Jeon, Ha Il Kim, Jin Won Huh
Korean J Crit Care Med. 2015;30(2):128-131.   Published online May 31, 2015
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AbstractAbstract PDF
Wernicke’s encephalopathy is a reversible but potentially critical disease caused by thiamine deficiency. Most patients complain of symptoms such as ophthalmoplegia, ataxia and confusion. Heavy alcohol drinking is commonly associated with the disease, but other clinical conditions also can provoke it. In pregnant women, hyperemesis gravidarum can lead to the depletion of body thiamine due to poor oral intake and a high metabolic demand. We report a case of Wernicke’s encephalopathy following hyperemesis gravidarum in a 36-year-old female at 20 weeks of pregnancy, who visited our hospital because of shock with vaginal bleeding. This case suggests that although the initial presentation may include atypical symptoms (e.g., shock or bleeding), Wernicke’s encephalopathy should be considered, and thiamine replacement should be performed in pregnant women with neurologic symptoms and poor oral intake.


Citations to this article as recorded by  
  • Wernicke's Encephalopathy in Acute and Chronic Kidney Disease: A Systematic Review
    Erik Oudman, Jan W. Wijnia, David Severs, Misha J. Oey, Mirjam van Dam, Maaike van Dorp, Albert Postma
    Journal of Renal Nutrition.2024; 34(2): 105.     CrossRef
  • Intrauterine Fetal Demise: A Rare Complication of Wernicke's Encephalopathy Secondary to Hyperemesis Gravidarum
    Anthony Pham, Robin Okpara, Nancy Rollins, Roy Jacob
    Cureus.2023;[Epub]     CrossRef
  • Wernicke’s encephalopathy in hyperemesis gravidarum: A systematic review
    Erik Oudman, Jan W. Wijnia, Misha Oey, Mirjam van Dam, Rebecca C. Painter, Albert Postma
    European Journal of Obstetrics & Gynecology and Reproductive Biology.2019; 236: 84.     CrossRef

ACC : Acute and Critical Care