Acute and Critical Care

Review Article

Basic science and research
Extracorporeal circulation models in small animals: beyond the limits of preclinical research: Mukhammad Kayumov, Reverien Habimana, Dowan Kim, Francis O Obiweluozor, In Seok Jeong, Hwa Jin Cho; Acute Crit Care. 2023;38(1):1-7. Published online February 28, 2023; DOI: https://doi.org/10.4266/acc.2023.00381

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Extracorporeal membrane oxygenation (ECMO) use has remarkably increased in recent years. Although ECMO has become essential for patients with refractory cardiac and respiratory failure, extracorporeal circulation (ECC) is associated with significant complications. Small-animal models of ECC have been developed and widely used to better understand ECC-induced pathophysiology. This review article summarizes the development of small-animal ECC models, including the animal species, circuit configuration, priming, perioperative procedures, cannulation, and future perspectives of small-animal ECMO models.

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Venoarterial Extracorporeal Membrane Oxygenation Implementation in Septic Shock Rat Model
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ASAIO Journal.2024;[Epub] CrossRef
Multiorgan recovery in a cadaver body using mild hypothermic ECMO treatment in a murine model
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Intensive Care Medicine Experimental.2023;[Epub] CrossRef
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Animals.2023; 13(22): 3532. CrossRef

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