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Original Article
- Immunology
- Serum procalcitonin and C-reactive protein as indices of early sepsis and mortality in North Indian pediatric burn injuries: a prospective evaluation and literature review
- Nupur Aggarwal, Durga Karki, Rajni Gaind, Monika Matlani, Vamseedharan Muthukumar
- Acute Crit Care. 2024;39(3):350-358. Published online August 30, 2024
- DOI: https://doi.org/10.4266/acc.2023.00759
- 9,425 View
- 330 Download
- 2 Web of Science
- 4 Crossref
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Abstract
PDF - Background
Delays in diagnosing sepsis in children afflicted with thermal injuries can result in high morbidity and mortality. Our study evaluated the role of the biomarkers Procalcitonin (PCT) and C-reactive protein (CRP) as predictors of early sepsis and mortality, respectively, in this group of patients.
Methods
This was a prospective evaluation of 90 pediatric burn cases treated at a tertiary care burn center in Northern India. Patients, aged 1–16 years, presenting within 24 hours of being burned, with >10% body surface area of burn injury were included in the study. Levels of PCT and CRP were measured on days 1, 3, 5, and 7. Patients were followed until discharge, 30th post-burn day, or death, whichever occurred first.
Results
Sepsis was clinically present in 49 of 90 (54.4%) cases with a median 30% total body surface area (TBSA) of burns. Mortality was seen in 31 of 90 (34.4%) cases with a median of 35% TBSA burns. High PCT and CRP were seen in the sepsis group, particularly on days 3, 5, and 7. PCT was also significantly higher in the mortality group (days 1 and 3).
Conclusions
While PCT was a good early predictor of sepsis and mortality in children with burns, CRP was reliable as a predictor of sepsis only. Both markers, however, can serve as adjuncts to culture sensitivity reports for diagnosing early onset sepsis and initiation of antibiotic therapy in appropriate patients. -
Citations
Citations to this article as recorded by
- Predictive Value of Inflammatory Burden Index for Sepsis in Critically Ill Patients with Extensive Burns: A Decade-Long Cohort Study
Songwei Zhou, Xin He, Yuqun Huang, Wei Zhu, Huapei Song
Journal of Inflammation Research.2026; Volume 19: 1. CrossRef - Infectious complications of burns in the intensive care unit
Alain Fennessy, Laura Slattery, Odhran Shelley, Luis Felipe Reyes, Ignacio Martin-Loeches
Journal of Critical Care.2026; 94: 155519. CrossRef - Refining mortality risk stratification in pediatric sepsis: the roles of PELOD-2, vasoactive-inotropic scores, and procalcitonin in a tertiary hospital in Eastern Indonesia
Arya Krisna Manggala, Dyah Kanya Wati, Ida Bagus Gede Suparyatha, I Nyoman Budi Hartawan
Acute and Critical Care.2026; 41(2): 387. CrossRef - Research Progress on Immune Inflammatory Response in Severe Burn and the Treatment with Ulinastatin
祺 马
Advances in Clinical Medicine.2025; 15(05): 896. CrossRef
- Predictive Value of Inflammatory Burden Index for Sepsis in Critically Ill Patients with Extensive Burns: A Decade-Long Cohort Study
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