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Korean J Crit Care Med > Volume 28(3); 2013 > Article
Korean Journal of Critical Care Medicine 2013;28(3): 187-191. doi: https://doi.org/10.4266/kjccm.2013.28.3.187
낭성 섬유증이 없었던 환자에서 폐이식 후 발생한 Burkholderia cepacia 폐렴
조진선ㆍ나성원ㆍ박무석*ㆍ소 윤ㆍ이 반ㆍ고신옥ㆍ백효채†
연세대학교 의과대학 마취통증의학교실, *내과학교실, †흉부외과학교실
A Case of Burkholderia cepacia Pneumonia after Lung Transplantation in a Recipient without Cystic Fibrosis
Jin Sun Cho, Sungwon Na, Moo Suk Park, Yun So, Bahn Lee, Shin Ok Koh, Hyo Chae Paik
1Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea.
2Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
3Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul, Korea. HCPAIK@yuhs.ac
ABSTRACT
Burkholderia cepacia is a highly virulent pathogen known to cause opportunistic infections in immunocompromised patients. It accelerates lung disease and causes necrotizing pneumonia with associated severe sepsis, known as cepacia syndrome. In particular, lung transplant recipients infected with Burkholderia cepacia show higher mortality after lung transplantation than those who are not infected with this organism. Due to broad-spectrum antibiotic resistance, a combination therapy should be used according to the results of the susceptibility test. This bacterial infection is rare in Korea, and no case was reported in lung transplant recipients. However, we report a case of pneumonia caused by Burkholderia cepacia after lung transplantation. As Burkholderia cepacia was grown from a sputum culture, the patient was treated initially with a combination of meropenem and trimethoprim/sulfamethoxazole and then ceftazidime and trimethoprim/sulfamethoxazole as a result of leukopenia. After antibiotics treatment for 20 days, sputum cultures became negative for Burkholderia cepacia and the patient successfully recovered.
Key Words: Burkholderia cepacia; lung transplantation; pneumonia
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