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Acute and Critical Care > Volume 36(1); 2021 > Article
Martelli and Tiberio: Pneumothorax and pulmonary air leaks as ventilator-induced injuries in COVID-19
Pneumothorax and other manifestations of pulmonary air leak (pneumomediastinum, subcutaneous emphysema) are well-known complications of coronavirus disease 2019 (COVID-19). The overall incidence of these complications in COVID-19 patients has been estimated to be 1% [1]. However, in mechanically ventilated COVID-19 patients, the incidence of pneumothorax and air leaks rises to 15% [2]. Despite the widespread use of protective ventilation techniques these complications remain a major concern. Severe cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia present with acute alterations such as pulmonary edema and diffuse alveolar damage [3], with a classical acute respiratory distress syndrome pattern. As a result of acute-phase alterations, there may be a negative evolution towards parenchymal consolidations and fibrosis. Due to these processes, COVID-19 patients could present with inhomogeneous pulmonary parenchyma and reduced compliance. Inhomogeneous parenchyma facilitates acute air leaks through the maldistribution of ventilatory stress (Figure 1) because two contiguous lung zones with different elasticity develop different local stresses [4]. Reduced compliance promotes lung injury and also tends to hinder re-expansion of the lungs after air drainage (Figure 2). These factors are also involved in self-inflicted lung injury [5] and could explain the growing number of cases of pneumothorax and acute air leaks in COVID-19 patients undergoing noninvasive protective ventilation (Figure 3).

NOTES

CONFLICT OF INTEREST

No potential conflict of interest relevant to this article was reported.

AUTHOR CONTRIBUTIONS

Conceptualization, Visualization, Writing–original draft: GM. Writing–review & editing: all author.

Figure 1.
Chest X-ray (A) and computed tomography thoracic scan (B) of a 59-year-old male coronavirus disease 2019 (COVID-19) patient after 3 days of invasive ventilation. Ventilation occurred in pressure-control mode with the following parameters: peak inspiratory pressure, 27 cm H2O; positive end-expiratory pressure, 12 cm H2O; fraction of inspired oxygen, 0.6; inspiratory to expiratory ratio, 1:2; and respiratory rate, 16. The last measurement prior to the occurrence of pneumothorax was a plateau pressure of 25 cm H2O and static compliance of 43 L/cm H2O. Bilateral inhomogeneous parenchyma and consolidative aspects of the left lung were noted. The patient developed left pneumothorax and pneumomediastinum. On chest X-ray, subcutaneous emphysema is evident.
acc-2020-00955f1.jpg
Figure 2.
Thoracic computed tomography axial scans of a 75-year-old coronavirus disease 2019 (COVID-19) patient with moderate acute respiratory distress syndrome. The scans were obtained at (A) upper, (B) middle, and (C) lower thoracic level. The patient was receiving pressure support ventilation (pressure support, 14 cm H2O; positive end-expiratory pressure, 10 cm H2O; fraction of inspired oxygen, 0.75; and mean respiratory rate, 18). These scans revealed a failure of lung re-expansion after right thoracic drainage (black arrow) and persistence of pneumothorax, pneumomediastinum, and subcutaneous emphysema.
acc-2020-00955f2.jpg
Figure 3.
Chest X-ray of a 40-year-old male coronavirus disease 2019 (COVID-19) patient. Right pneumothorax of 30 mm. “Deep sulcus sign” was noted (black arrow). This patient developed pneumothorax after a cycle of non-invasive ventilation with a helmet interface. Ventilation was set at pressure support, 8 cm H2O; positive end-expiratory pressure, 10 cm H2O; and fraction of inspired oxygen, 0.55.
acc-2020-00955f3.jpg

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