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Korean J Crit Care Med > Volume 24(3); 2009 > Article
Korean Journal of Critical Care Medicine 2009;24(3): 168-171. doi: https://doi.org/10.4266/kjccm.2009.24.3.168
지연성 악성 과체온증-증례 보고-
대전선병원 신경외과
Delayed Onset of Malignant Hyperthermia: A Case Report
Jeong Wook Lim, Seok Kon Yeo, Seong Hwan Yang, In Seok Hwang, Jong Soo Lee
Department of Neurosurgery, Daejeon Sun General Hospital, Daejeon, Korea. magicdoctor@hanmail.net
Malignant hyperthermia is a potentially fatal genetic and metabolic myopathy that presents with high fever, and muscle rigidity, and it often occurs after administering anesthetic medication. Most cases of malignant hyperthermia occur during anesthesia or surgery, but delayed malignant hyperthermia is very rare, and if it is detected late, it has a high mortality rate. A 39-year-old male with an acute subdural hematoma underwent decompressive craniectomy without any intraoperative medical problems, but a high fever above 40degrees C occurred after 8 hours and he was dead in spite of aggressive management after 48 hours postoperatively. We present here a case of delayed malignant hyperthermia along with a review of the related literature.
Key Words: delayed malignant hyperthermia; ryanodine receptor; sevoflurane
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