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Korean J Crit Care Med > Volume 17(2); 2002 > Article
Korean Journal of Critical Care Medicine 2002;17(2): 95-99.
원저 : 백서에서 Propofol이 경부교감신경 차단 후 Mannitol에 의한 혈뇌장벽 개방도에 미치는 영향
이진영, 윤수한, 김재형, 채윤정, 이영주, 김진수, 문봉기
아주대학교 의과대학 마취통증학교실, *신경외과학교실
The Effects of Propofol on Blood-Brain Barrier Disruption with Mannitol Infusion in Cervical Sympathetic Nerve Blocked Rats
Jin Young Lee, Soo Han Yoon, Jae Hyung Kim, Yun Jeong Chae, Young Joo Lee, Jin Soo Kim, Bong Ki Moon
1Department of Anesthesiology, College of medicine, Ajou University, Suwon, Korea. mbk@madang.ajou.ac.kr
2Department of Neurosurgery, College of medicine, Ajou University, Suwon, Korea.
ABSTRACT
BACKGROUND: Blood brain barrier disruption (BBBD)increases therapeutic agents delivery to brain diseases.Increasing the delivery of therapeutic drugs to the brainimproves out come f or patients with brain tumors.Cervical sympathetic chain block can increase the degree of mannitol induced blood brain barrier disruption in rats.Anesthetic agents may modify hyperosmolar blood brain barrier disruption.Therefore we evaluated the effecfs of pentobarbital and propofol on mannitol induced blood brain barrier disruption(BBBD)in cervical sympathetic nerve blocked rats. METHODS: 14 male Sprague-Dawley rats were divided into 2 groups.Intravenous pentobarbital (group 1,n=7)and propofol (group 2,n=7)were administrated.Rats was blocked with 0.5% bupivacaine on right cervical sympathetic chain.All rats received 37degrees C,25%mannitol (1.75 g/kg) via right carotid artery.BBBD was estimated by Evans blue staining in cerebral hemisphere. RESULTS: Both groups showed BBBD in right side hemisphere and there was no significant difference between group 1 and group 2 in right side hemisphere. CONCLUSIONS: The results suggest that propofol could be used to be anesthetics for BBBD in cervical sympathetic blocked rats.
Key Words: Blood brain barrier disruption; Cervical sympathetic chain block; Pentobarbital; Propofol
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