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Korean J Crit Care Med > Volume 16(1); 2001 > Article
Korean Journal of Critical Care Medicine 2001;16(1): 48-54.
원저 : 백서에서 Endotoxin이 뇌척수액 생성에 미치는 영향
김동찬, 김유정, 민기철
전북대학교 의과대학 마취고학교실, 임상의학연구소, 대학원 의학과
Effect of Endotoxin on Cerebrospinal Fluid Formation in the Rat
Dong Chan Kim, Yu Jeong Kim, Gi Chul Min
Department of Anesthesiology, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, Korea.
BACKGROUND: Bacterial lipopolysaccharide (LPS), an endotoxin, can increase nitric oxide (NO) production by expression of an inducible isoforms of nitric oxide synthase (iNOS). Bacterial infections of the central nervous system dilate cerebral vessels and increase cerebral blood flow. We hypothesized that systemic and intraventricular application of bacterial lipopolysaccharide would increase cerebrospinal fluid (CSF) production due to increase in blood flow to choroid plexus caused by NO-induced vasodilation. METHODS: Ventriculocisternal perfusion was used to measure the production of CSF in pentobarbital-anesthetized rats. The lateral ventricle and cisterna magna were cannulated stereotactically and perfused continuously with artificial CSF with blue dextran 2000 as the indicator. Baseline collections of CSF began after steady state outflow was established; then, endotoxin was administered intravenously or intraventricularly. The baseline rate of CSF production was compared with that measured during 3 hours after endotoxin administration. RESULTS: The baseline rate of CSF production was 2.6 0.3 (2.2~3.5)microliter/minute in the rat. There were no significant changes in CSF production rate after intravenous or intraventriculr administration of endotoxin. CONCLUSIONS: We could not observe significant changes in CSF production rate with the ventriculocisternal perfusion method of measuring CSF production after intravenous or intraventriculr administration of endotoxin in the rats.
Key Words: Cerebrospinal fluid formation; Endotoxin; Ventriculocisternal perfusion
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