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Korean J Crit Care Med > Volume 14(2); 1999 > Article
Korean Journal of Critical Care Medicine 1999;14(2): 132-136.
마그네슘의 정맥내 전처치가 고양이의 급성 뇌허혈 - 재관류 모델에서 뇌에너지 대사에 미치는 효과 : 31P 및 1H 자기공명분광기를 이용한 연구
석은하, 강지영, 천성관, 박평환, 임근호, 이정희, 임태환
울산대학교 의과대학 마취과학교실, 1아산생명과학연구소 NMR실 및 2진단방사선과학교실
Effects of Mg2+ Intravenous Pretreatment on Brain Energy Metabolism in Acute Ischemic-Reperfusion Model in Cats: 31P and 1H Magnetic Resonance Spectroscopic Study
Eun Ha Suk, Ji Young Kang, Sung Kwan Chun, Pyung Hwan Park, Kun Ho Lim, Jung Hee Lee, Tae Hwan Lim
1Department of Anesthesiology, Asan Medical Center,College of Medicine, University of Ulsan, Seoul, Korea.
2NMR Laboratory, Asan Medical Center,College of Medicine, University of Ulsan, Seoul, Korea.
3Diagnostic Radiology, Asan Medical Center,College of Medicine, University of Ulsan, Seoul, Korea.
ABSTRACT
BACKGOUND: This study was purposed to evaluate the effects of Mg2+ pretreatment on cerebral ischemic injury in cats. METHODS: Global cerebral ischemia was induced by ligation of both innominate arteries following ligation of inferior vena cava under lowered mean blood pressure for 20 minutes followed by 3 hrs of reperfusion. Ten cats were divided into 2 groups: Group 1 (n=5) is the control group, for group 2 (n=5) (Mg2+ group), the animals were pretreated with 90 mg/kg of Mg2+ intravenously before subjected to ischemia. RESULTS: Phosphocreatine/inorganic phosphate (Pcr/Pi) and pH decreased after ischemia and did not recovered during reperfusion. And there were no significant differences between the two groups. The ratios of lactate/N-acetyl aspartate (Lac/NAA) and lactate/creatine (Lac/Cr) increased after ischemia and not recovered during reperfusion. But the ratios were higher for the group 2 than the group 1 during reperfusion (p<0.05). For the Mg2+ group, blood pressure during reperfusion was lower than the control group. CONCLUSIONS: Mg2+ intravenous pretreatment had no protective effect on this global cerebral ischemia animal model. Even it deteriorated brain energy metabolism by lowering blood pressure.
Key Words: Brain; ischemia; metabolism; Pharmacology; Mg2+
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