Oxygenation Index in the First 24 Hours after the Diagnosis of Acute Respiratory Distress Syndrome as a Surrogate Metric for Risk Stratification in Children

Article information

Acute Crit Care. 2018;33(4):222-229
Publication date (electronic) : 2018 November 29
doi : https://doi.org/10.4266/acc.2018.00136
1Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
2Department of Pediatrics, Hanyang University College of Medicine, Seoul, Korea
3Sowha Children’s Hospital, Seoul, Korea
Corresponding author Kyung Won Kim Department of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea Tel: +82-2-2228-2050 Fax: +82-2-393-9118 E-mail: kwkim@yuhs.ac
Received 2018 April 20; Revised 2018 August 10; Accepted 2018 August 27.

Abstract

Background

The diagnosis of pediatric acute respiratory distress syndrome (PARDS) is a pragmatic decision based on the degree of hypoxia at the time of onset. We aimed to determine whether reclassification using oxygenation metrics 24 hours after diagnosis could provide prognostic ability for outcomes in PARDS.

Methods

Two hundred and eighty-eight pediatric patients admitted between January 1, 2010 and January 30, 2017, who met the inclusion criteria for PARDS were retrospectively analyzed. Reclassification based on data measured 24 hours after diagnosis was compared with the initial classification, and changes in pressure parameters and oxygenation were investigated for their prognostic value with respect to mortality.

Results

PARDS severity varied widely in the first 24 hours; 52.4% of patients showed an improvement, 35.4% showed no change, and 12.2% either showed progression of PARDS or died. Multivariate analysis revealed that mortality risk significantly increased for the severe group, based on classification using metrics collected 24 hours after diagnosis (adjusted odds ratio, 26.84; 95% confidence interval [CI], 3.43 to 209.89; P=0.002). Compared to changes in pressure variables (peak inspiratory pressure and driving pressure), changes in oxygenation (arterial partial pressure of oxygen to fraction of inspired oxygen) over the first 24 hours showed statistically better discriminative power for mortality (area under the receiver operating characteristic curve, 0.701; 95% CI, 0.636 to 0.766; P<0.001).

Conclusions

Implementation of reclassification based on oxygenation metrics 24 hours after diagnosis effectively stratified outcomes in PARDS. Progress within the first 24 hours was significantly associated with outcomes in PARDS, and oxygenation response was the most discernable surrogate metric for mortality.

INTRODUCTION

Acute respiratory distress syndrome (ARDS) refers to a condition of acute lung injury and inflammation that leads to hypoxic respiratory failure. Although there is general agreement that ARDS can affect people of all ages [1], the original and revised definitions of ARDS (i.e., the American-European Consensus Conference definition in 1994 [2] and the Berlin definition in 2012 [3]) did not include pediatric considerations. As the pediatric population exhibits a distinctive epidemiology and prognosis [4], as well as intrinsic differences in respiratory physiology [5], the Pediatric Acute Lung Injury Consensus Conference (PALICC) established new definitions for pediatric ARDS (PARDS) in 2015 [6]. The key differences included in these PALICC criteria are the use of an oxygenation index (OI) for severity stratification instead of the ratio of the arterial partial oxygen pressure to the fraction of inspired oxygen (PaO2/FiO2), allowance for pulse oximetry-based metrics (e.g., oxygenation saturation index [OSI]) when PaO2 is not available, less stringent chest radiograph standards, and a broader scope by including subjects with chronic lung disease and cyanotic heart disease [6].

The incidence of PARDS is reported as 1%–4% of pediatric intensive care unit (ICU) admissions [7,8]. Despite improvements in the quality of intensive care, PARDS still is a major challenge in the pediatric ICU due to mortality as high as 30% [7,9]. As most treatment strategies for PARDS have been extrapolated from evidence gathered in adult studies, there is a growing need for interventional trials focused on pediatric populations. Likewise, risk stratification and identification of high-risk cases of PARDS have been attempted to better understand patient populations and optimize the quality of care.

Although the above definitions use oxygenation metrics as a primary indicator for lung injury, there remains a lack of guidance regarding when clinicians should acquire the metrics for PARDS risk stratification. With regard to PaO2/FiO2, OI and OSI are influenced by ventilator settings [10-12] and vary according to the disease progression; thus, the timing of measuring these metrics should be considered during risk stratification. Notably, several recent reports [8,13,14] have shown that mortality discrimination in PARDS is improved with the use of oxygenation metrics within the first 24 hours after onset relative to using initial metrics.

In this study, we aimed to determine whether reclassification using oxygenation metrics 24 hours after diagnosis of PARDS would have prognostic ability in an Asian cohort. Respiratory variables to be used as early prediction factors for risk stratification in PARDS were also investigated.

MATERIALS AND METHODS

Patient Selection

A total of 1,101 patients aged 1 month to 19 years who were treated in the medical ICU of a medical ICU of Severance Hospital between January 1, 2010 and January 30, 2017 were screened for inclusion in this study. All pediatric patients admitted to the medical ICU during this period were identified using an electronic database search, and two of the authors (SYK and BK) identified patients who fulfilled the following eligibility criteria: (1) acute respiratory failure requiring invasive mechanical ventilation, (2) at least one documented arterial blood-gas result at the time of PARDS diagnosis, (3) diagnosis of PARDS according to the PALICC criteria, and (4) age older than 1 month. The exclusion criteria were as follows: (1) respiratory failure due to cardiac failure or fluid overload, (2) congenital cyanotic heart disease, and (3) initiation of mechanical ventilation for more than 7 days before fulfilling OI ≥4. For the patients who met the inclusion criteria, clinical data were collected from the electronic medical records and analyzed retrospectively. This study was approved by the Institutional Review Board of the Institutional Review Board of Severance Hospital (IRB No. 4-2013-0207), and the informed consent requirement was waived.

Data Collection and Variable Definitions

Demographics and clinical data, including PARDS etiology, comorbidity, Pediatric Risk of Mortality (PRISM) III score, clinical progress, and outcomes, were assessed. The oxygenation metrics obtained were PaO2/FiO2 ratio, OI [(mean airway pressure×FiO2×100)/PaO2], and OSI [(mean airway pressure ×FiO2×100)/SpO2]. All patients were classified according to the PALICC criteria [15] using the oxygenation metrics at the time of diagnosis and 24 hours afterward as follows: (1) mild PARDS, 4≤ OI <8 or 5≤ OSI <7.5, (2) moderate PARDS, 8≤ OI <16 or 7.5≤ OSI <12.3, and (3) severe PARDS, OI ≥16 or OSI ≥12.3. Data regarding mechanical ventilation, including ventilator mode, peak inspiratory pressure (PIP), positive endexpiratory pressure (PEEP), mean airway pressure, tidal volume (TV), and FiO2, were recorded at the time of PARDS diagnosis and 24 hours later. Driving pressure was defined as the difference between the PIP and PEEP. Changes in these variables over the first 24 hours (ΔPaO2/FiO2, Δdriving pressure, and ΔPIP) were also determined.

In our institution, general patient management in cases of progressive respiratory failure is performed using mechanical ventilation strategies with a minimal PEEP of 5 cmH2O, escalation to 8–10 cmH2O in cases of inability to wean FiO2 below 0.60, and attempts to maintain PIP below 30–35 cmH2O with TV <5–8 mL/kg. Although there is no specific target PaO2, a PaO2 of at least 60 mmHg is typically accepted in cases if the hemodynamics and tissue oxygenation appear adequate. Decelerating flow with either pressure-regulated volume control or pressure control mode of ventilation was used in the majority of cases. As both oxygenation [13,16] and driving pressure [17] are associated with mortality in ARDS, pressure parameters (e.g., PIP and driving pressure) and oxygenation were investigated for their prognostic ability.

The reported outcomes are ICU mortality and ventilator-free days (VFDs) at 28 days postdiagnosis. All instances of “ventilation” in this study indicate invasive ventilation; noninvasive support was not counted toward the ventilator days. VFDs were determined for survivors by subtracting the total duration of ventilation from 28 days. Patients who required ≥28 ventilator days and all ICU non-survivors were designated as VFD=0. This composite endpoint, which incorporates both mortality and length of ventilation by penalizing non-survivors, is among the most commonly used surrogate endpoints in recent PARDS studies [18].

Statistical Analysis

The data are expressed as either percentages or medians with interquartile range (IQR). Categorical variables were analyzed using the chi-square test or Fisher exact test, and continuous variables were compared using the Mann-Whitney U-test. The main outcomes of PARDS were mortality and VFDs at day 28; VFDs were dichotomized into 0 days versus >0 days and into ≤14 days versus >14 days. Multivariate logistic regression was performed to test for associations between severity classifications and main outcomes, adjusting for age, sex, PRISM III score, comorbidity, and PARDS etiology. Initial progress during the first 24 hours was divided into maintaining or worsening severity versus improving severity, which were evaluated for associations with the outcomes. Receiver operating characteristic (ROC) analysis was employed to evaluate the discriminative ability of each classification at different time points for mortality and VFDs using the area under the curve with 95% confidence intervals (CIs); comparisons between the two curves were made using DeLong’s test.

All statistical analyses were performed with R software version 3.2.2 (R Foundation, Vienna, Austria) and IBM SPSS version 23.0 (IBM Corp., Armonk, NY, USA). Statistical significance was defined as P<0.05.

RESULTS

Characteristics of Study Population

A total of 288 pediatric patients who met the inclusion criteria were included in this analysis. The characteristics of the overall study population and of each group, stratified according to survival status, are summarized in Table 1. Chronic comorbidities were present in 127 patients (44.1%); the most common conditions were oncologic (45.5%) and neurologic (44.2%). Infectious pneumonia (63.2%) and sepsis (21.2%) composed the majority of PARDS triggers. The median length of ICU stay was 11 days (IQR, 5 to 21 days), the median duration of mechanical ventilation was 9 days (IQR, 5 to 20 days), and the overall mortality rate was 38.9%.

Demographics and baseline characteristics of the study population

PARDS Severity Changes during the First 24 Hours

At initial diagnosis, 121 (42.0%), 99 (34.4%), and 68 (23.6%) patients met the criteria for the mild, moderate, and severe categories, respectively (Table 1). Twenty-four hours later, 25 patients had died, and 187 out of the remaining 263 patients (71.1%) continued to meet the PARDS criteria; of those, 93 cases (49.7%) were mild, 51 (27.3%) were moderate, and 43 (23.0%) were severe. In the entire cohort, 151 patients (52.4%) improved in severity or recovered from PARDS, 102 (35.4%) maintained a stable presentation of the disease, and 35 (12.2%) either exhibited aggravated disease severity or died within the first 24 hours. There were no intergroup differences according to initial PARDS severity with respect to changes in severity (data not shown).

Association of Classification at Different Time Points with Outcomes in PARDS

The classifications of the patients into severity groups at the time of PARDS diagnosis and 24 hours afterward are depicted in Figure 1. Both classifications demonstrated a stepwise increase in mortality with increasing disease severity: mild PARDS (n=121; mortality, 25.6%), moderate PARDS (n=99, 36.4%), and severe PARDS (n=68, 66.2%) according to metrics at diagnosis; mild PARDS (n=93, 30.1%), moderate PARDS (n=51, 41.2%), and severe PARDS (n=43, 88.4%) according to metrics at 24 hours. Significant differences in mortality were noted with severe PARDS compared to either mild or moderate PARDS (mild vs. severe PARDS, P<0.001; moderate vs. severe PARDS, P<0.001) in both classifications. Multivariate logistic regression analysis showed that the risk for mortality significantly increased for the severe group under both classifications (adjusted odds ratio [OR], 7.16; 95% CI, 2.02 to 25.31; P=0.002 for severe group at diagnosis, and adjusted OR, 26.84; 95% CI, 3.43 to 209.89; P=0.002 for severe group at 24 hours). Similar results were found for patients having no VFDs at day 28 (Table 2). Subsequent ROC analysis demonstrated no differences in the discriminative ability of either mortality or VFDs between both classifications (Supplementary Figure 1).

Figure 1.

Classification of patients into Pediatric Acute Lung Injury Consensus Conference oxygenation categories based on metrics at the time of diagnosis (A) and 24 hours afterward (B). Both classification methods demonstrated a stepwise increase in mortality with increasing disease severity: mild PARDS (n=121, mortality=25.6%), moderate PARDS (n=99, 36.4%), and severe PARDS (n=68, 66.2%) according to metrics at diagnosis; mild PARDS (n=93, 30.1%), moderate PARDS (n=51, 41.2%), and severe PARDS (n=43, 88.4%) according to metrics at 24 hours later. PARDS: pediatric acute respiratory distress syndrome. *Mild PARDS vs. severe PARDS: P<0.001; **Moderate PARDS vs. severe PARDS: P<0.001.

Multivariate regression analysis of association of classification at different time points with outcomes in PARDS

Associations of Initial Progress with Outcomes

Initial progress was divided into maintaining or worsening severity versus improving severity. Survivors exhibited a significantly higher proportion of subjects with improved severity during the first 24 hours compared with non-survivors (67.0% and 29.5%, respectively; P<0.001) (Table 1). Logistic regression analysis revealed an association between initial progress over the first 24 hours with PARDS outcomes after adjustment for potential covariates such as age, sex, PRISM III score, comorbidity, and PARDS etiology. Maintaining or worsening severity was significantly associated with mortality (adjusted OR, 4.52; 95% CI, 1.84 to 11.08; P=0.001) and VFD=0 at day 28 (adjusted OR, 4.62; 95% CI, 2.00 to 10.70; P<0.001) (Table 3).

Multivariate regression analysis of association of initial progress with outcomes in PARDS

Discriminative and Predictive Ability of Early Oxygenation Response

Based on the ROC analysis, ΔPaO2/FiO2, Δdriving pressure, and ΔPIP all discriminated mortality and VFD, but the AUC of ΔPaO2/FiO2 was consistently higher than the AUCs of the other factors (Table 4). For mortality, the AUC of ΔPaO2/FiO2 was statistically higher compared to that of either Δdriving pressure or ΔPIP (Supplementary Figure 2), indicating superior predictive validity. Regression analysis confirmed that increasing PaO2/FiO2 was significantly associated with increased mortality and decreased VFD (Table 5). After adjusting for age, sex, PRISM III score, comorbidities, PARDS etiology, and initial PALICC oxygenation severity, an OR of 1.09 was determined for the odds of death with each increase of 10 in PaO2/FiO2 (P=0.002) over the first 24 hours (95% CI, 1.03 to 1.15). Similarly, an increase of 10 in PaO2/FiO2 resulted in an OR of 1.05 for VFD=0 at day 28 (95% CI, 1.00 to 1.09; P=0.031) (Table 5).

Discriminative ability of respiratory variables for mortality and VFD

Multivariate regression analysis of association of initial oxygenation response with outcomes in PARDS

DISCUSSION

In this study, PARDS severity changed frequently in the first 24 hours after diagnosis. Reclassification 24 hours after diagnosis provided similar effectiveness in outcome stratification of PARDS subjects compared with classification by using the initial metrics. Notably, progress within the first 24 hours was significantly associated with mortality and VFDs. Among a variety of clinical variables in this early timeframe, changes in oxygenation provided the most discernible predictor for outcomes in PARDS.

Several groups have demonstrated the discriminative ability of oxygenation metrics 24 hours after onset for outcomes in ARDS compared with those of metrics at onset [8,13,14]. Yehya et al. [13] reported that PaO2/FiO2 and OI, measured 24 hours after meeting ARDS criteria, accurately stratified the severity of lung injury. Parvathaneni et al. [14] reported up to 50% mortality in children who were categorized with severe ARDS at 24 hours. Although there was no difference in the discriminative power for mortality between PALICC criteria at diagnosis and 24 hours afterward, our findings revealed a significant association between initial progress within 24 hours and outcomes in PARDS. Subjects who showed identical or worsening severity within the first 24 hours exhibited an approximately three to four times higher risk for mortality and fewer VFDs. Moreover, those who were placed in the severe group at 24 hours demonstrated nearly 90% mortality, which implies a benefit for reclassification at 24 hours after PARDS diagnosis.

Although the cross-sectional nature of this study did not allow for determination of causality, the significant association of early progress in PARDS with final outcomes has critical implications. A possible hypothesis for this association is that differing responses to early phase resuscitation, including lung recruitment and subsequent improvement in ventilation/perfusion mismatches, might lead to different disease progression after onset. Indeed, the severity of PARDS changed widely in the first 24 hours, such that nearly two-thirds of patients were reclassified into categories of different severity. As there were no differences in these category changes in terms of the initial severity of PARDS, our results also highlight the importance of early interventions in the management of PARDS. Future prospective trials with larger cohorts are required to establish evidence-based interventions regarding populations who are most likely to benefit from changes in treatment within the first 24 hours.

Interestingly, we have shown that improvement in oxygenation was the most discernable predictor for outcomes in PARDS. Although changes in PIP, driving pressure, and PEEP also discriminated outcomes, ΔPaO2/FiO2 demonstrated superior prognostic ability for mortality compared with the other variables. This finding is consistent with a recent report by Yehya and Thomas [19] that verified that PaO2/FiO2 at 24 hours and ΔPaO2/FiO2 were exclusively associated with mortality, while pressure variables, including ΔPIP, Δdriving pressure, and ΔPEEP, were not. This distinguishing association between oxygenation response and survival indicates that oxygenation is a more appropriate surrogate metric for outcomes in PARDS compared with PIP or driving pressure. This finding raises questions regarding the beneficial effects of existing ventilation strategies in children that strictly limit TV and PIP [15,20]. Considering that the evidence for the effectiveness of low-TV ventilation in children has not been consistent [21], and that children exhibit a different respiratory physiology [5] that might result in dissimilar susceptibility to ventilator-induced lung injury compared to adults, detailed prospective trials are needed in children to identify the proper upper limits of TV, PIP, and driving pressure to achieve appropriate oxygenation.

In this study, PARDS occurred in approximately 26.2% of all ICU admissions of children. This prevalence was much higher than in previous reports [7]. Moreover, the overall mortality rate of 38.9% was higher than the rates of previous studies performed in North America [13,14,22] and Europe [8,23,24]. These discrepancies may result from differences in resources, socioeconomic circumstances, and patient characteristics. In our center, pediatric patients shared an ICU with adult patients until the year 2016, when the pediatric ICU was first established. For countries with limited resources, the indications for ICU admission are relatively more stringent than in more developed countries, which might lead to this increased incidence of PARDS in the ICU. Indeed, a recent meta-analysis demonstrated that studies performed in Asia had higher overall mortality than studies performed in Western countries [7]; the mortality result in our study is within the range of reported mortality in Asia [25-27]. In addition, postsurgical, cardiac, and neonatal cases are treated in separate specialized units in our center. As we have a large number of patients in the hematologyoncology and epilepsy centers, an increased incidence of these comorbidities might contribute to the increased mortality. In this study, logistic regression analysis demonstrated that mortality was significantly higher in subjects with those comorbidities (data not shown). Finally, subjects included in this study were confined to those who underwent at least one arterial blood-gas study; thus, mild cases could have been excluded. In this context, our findings demonstrate that PARDS remains a common cause of death in the field of pediatric critical care.

We acknowledge several limitations to this study. First, our study was conducted using a limited number of patients, since this was a single-center study. Second, treatment protocols regarding ventilator management might have varied over time. Third, our study results are limited to relatively short-term outcomes. In addition, since this study was retrospectively designed, we cannot exclude any possible bias regarding patient identification. Further prospective validations are needed to overcome the inherent limitations of this study design.

In conclusion, we demonstrated that the implementation of reclassification based on oxygenation metrics 24 hours after the initial diagnosis appropriately stratified outcomes in PARDS. Progress within the first 24 hours was significantly associated with mortality and ventilator free days in PARDS. Among the variables evaluated during this early phase, oxygenation response was the most discernable surrogate metric for mortality. These results may provide a framework to design future interventional trials in PARDS and to optimize clinical practices.

KEY MESSAGES

▪ Pediatric acute respiratory distress syndrome (PARDS) severity varied widely in the first 24 hours and the progress within this early timeframe was significantly associated with mortality and ventilator-free days.

▪ Improvement in oxygenation in the first 24 hours after the diagnosis was the most discernable predictor for outcomes in PARDS.

Notes

No potential conflict of interest relevant to this article was reported.

Acknowledgements

This work was supported by Institute for Information & Communications Technology Promotion grant funded by the Korea Government (MSIT) (No. 2017-0-00599, Development of Big Data Analytics Platform for Military Health Information).

Supplementary Materials

The online-only Supplement data are available with this article online: https://doi.org/10.4266/acc.2018.00136.

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Article information Continued

Figure 1.

Classification of patients into Pediatric Acute Lung Injury Consensus Conference oxygenation categories based on metrics at the time of diagnosis (A) and 24 hours afterward (B). Both classification methods demonstrated a stepwise increase in mortality with increasing disease severity: mild PARDS (n=121, mortality=25.6%), moderate PARDS (n=99, 36.4%), and severe PARDS (n=68, 66.2%) according to metrics at diagnosis; mild PARDS (n=93, 30.1%), moderate PARDS (n=51, 41.2%), and severe PARDS (n=43, 88.4%) according to metrics at 24 hours later. PARDS: pediatric acute respiratory distress syndrome. *Mild PARDS vs. severe PARDS: P<0.001; **Moderate PARDS vs. severe PARDS: P<0.001.

Table 1.

Demographics and baseline characteristics of the study population

Variable Total (n=288) Survived (n=176) Died (n=112) P-value
Sex (male:female) 169:119 100:76 69:43 <0.001
Age (yr) 3.7 (1.3-10.5) 2.5 (1.0-8.3) 6.0 (2.0-11.9) 0.495
PRISM III score 9.0 (5.0-14.5) 6.5 (3.0-11.0) 14.0 (9.0-20.0) <0.001
Comorbidity in ICU at admission <0.001
 Oncology 71 (45.5) 17 (20.0) 54 (76.1)
 Neurology 69 (44.2) 56 (65.9) 13 (18.3)
 Genetic syndrome 16 (10.3) 12 (14.1) 4 (5.6)
PARDS etiology <0.001
 Infectious pneumonia 182 (63.2) 130 (73.9) 52 (46.4)
 Aspiration pneumonia 33 (11.5) 23 (13.1) 10 (8.9)
 Sepsis 61 (21.2) 17 (9.7) 44 (39.3)
Initial PALICC grade <0.001
 Mild : moderate : severe 121:99:68 90:63:23 31:36:45
Progress over the first 24 hours <0.001
 Improvement in severity 151 (52.4) 118 (67.0) 33 (29.5)
Outcome
 ICU length of stay (day) 11.0 (5.0-21.0) 11.0 (7.0-21.0) 7.0 (2.0-22.0) 0.002
 Ventilator duration (day) 9.0 (5.0-20.0) 9.0 (6.0-18.0) 7.5 (3.0-23.0) 0.065
 VFDs at day 28 139 (48.3) 27 (15.3) 112 (100.0) <0.001

Values are presented as median (interquartile range) or number (%).

PRISM: Pediatric Risk of Mortality; ICU: intensive care unit; PARDS: pediatric acute respiratory distress syndrome; PALICC: Pediatric Acute Lung Injury Consensus Conference; VFD: ventilator-free day.

Table 2.

Multivariate regression analysis of association of classification at different time points with outcomes in PARDS

Variable Classification at diagnosis
Classification at 24 hours
Adjusted OR 95% CI P-value Adjusted OR 95% CI P-value
Mortality
 Mild (reference)
 Moderate 1.80 0.67-4.84 0.241 2.20 0.53-9.18 0.278
 Severe 7.16 2.02-25.31 0.002 26.84 3.43-209.89 0.002
VFD=0 at day 28
 Mild (reference)
 Moderate 1.73 0.73-4.11 0.213 1.58 0.41-6.16 0.507
 Severe 4.56 1.47-14.19 0.009 10.04 1.77-57.02 0.009
VFD ≤14 at day 28
 Mild (reference)
 Moderate 0.97 0.42-2.23 0.938 0.65 0.14-2.91 0.569
 Severe 8.29 1.70-40.46 0.009 6.51 0.63-67.16 0.116

ORs were adjusted for age, sex, PRISM III score, comorbidities, and PARDS etiology.

PARDS: pediatric acute respiratory distress syndrome; OR: odds ratio; CI: confidence interval; VFD: ventilator-free day; PRISM: Pediatric Risk of Mortality.

Table 3.

Multivariate regression analysis of association of initial progress with outcomes in PARDS

Variable Adjusted OR 95% CI P-value
Mortality
 Improvement (reference)
 Maintain or aggravation 4.52 1.84-11.08 0.001
VFD=0 at day 28
 Improvement (reference)
 Maintain or aggravation 4.62 2.00-10.70 <0.001
VFD ≤14 at day 28
 Improvement (reference)
 Maintain or aggravation 3.32 1.43-7.73 0.005

ORs were adjusted for age, sex, PRISM III score, comorbidities, and PARDS etiology.

PARDS: pediatric acute respiratory distress syndrome; OR: odds ratio; CI: confidence interval; VFD: ventilator-free day; PRISM: Pediatric Risk of Mortality.

Table 4.

Discriminative ability of respiratory variables for mortality and VFD

Variable Area under the curve 95% CI P-value
Mortality
 ΔPaO2/FiO2 0.701 0.636-0.766 <0.001
 ΔDriving pressure 0.570 0.498-0.641 <0.001
 ΔPIP 0.583 0.511-0.656 <0.001
VFD=0 at day 28
 ΔPaO2/FiO2 0.658 0.592-0.725 <0.001
 ΔDriving pressure 0.554 0.486-0.623 <0.001
 ΔPIP 0.578 0.509-0.646 <0.001
VFD ≤14 at day 28
 ΔPaO2/FiO2 0.613 0.543-0.683 <0.001
 ΔDriving pressure 0.584 0.516-0.652 <0.001
 ΔPIP 0.611 0.545-0.678 <0.001

VFD: ventilator-free day; CI: confidence interval; ΔPaO2/FiO2: changes in arterial partial pressure of oxygen to fraction of inspired oxygen for the first 24 hours; ΔDriving pressure: changes in driving pressure for the first 24 hours; ΔPIP: changes in peak inspiratory pressure for the first 24 hours.

Table 5.

Multivariate regression analysis of association of initial oxygenation response with outcomes in PARDS

Variable Adjusted OR 95% CI P-value
Maintained or aggravated severity 1.54 1.31-1.80 <0.001
Mortality 1.09 1.03-1.15 0.002
VFD=0 at day 28 1.05 1.00-1.09 0.031
VFD ≤14 at day 28 1.02 0.99-1.06 0.249

ORs were adjusted for age, sex, PRISM III score, comorbidities, PARDS etiology, and initial PALICC severity classification.

PARDS: pediatric acute respiratory distress syndrome; OR: odds ratio; CI: confidence interval; VFD: ventilator-free day; PRISM: Pediatric Risk of Mortality; PALICC: Pediatric Acute Lung Injury Consensus Conference.