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Korean J Crit Care Med > Volume 27(4); 2012 > Article
Korean Journal of Critical Care Medicine 2012;27(4): 274-278. doi: https://doi.org/10.4266/kjccm.2012.27.4.274
범저감마글로불린혈증 남아에서 발생한 주폐포자충 폐렴 1예
정보현ㆍ남효경ㆍ이영준ㆍ이광철ㆍ정지태ㆍ임춘학*ㆍ유 영
고려대학교 의과대학 소아과학교실, *마취통증의학교실
Pneumocystis jiroveci Pneumonia in a 5-month-old Boy with Agammaglobulinemia: A Case Report
Bo Hyun Chung, Hyo Kyoung Nam, Young Jun Rhie, Kwang Chul Lee, Ji Tae Choung, Choon Hak Lim, Young Yoo
1Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea. yoolina@korea.ac.kr
2Department of Anesthesiology and Pain Medicine, College of Medicine, Korea University, Seoul, Korea.
ABSTRACT
Pneumocystis jiroveci (P. jiroveci) pneumonia is known as a common opportunistic infection in patients with impaired immunity. Underlying disease or conditions related to the development of P. jiroveci pneumonia include acquired immunodeficiency syndromes, as well as malignancies and congenital immune deficiency disorders. We describe a 5-month-old boy without significant medical history who was admitted at our hospital because of fever, tachypnea, vomiting, diarrhea, and lethargy whose condition became worse within several hours after admission. A chest X-ray showed bilateral diffuse infiltration and high resolution computed tomography showed diffuse bilateral ground-glass opacity. The patient was diagnosed with P. jiroveci pneumonia by direct immunofluorescent antibody staining from lung biopsy and he was later diagnosed with agammaglobulinemia. Although the boy was treated with antibiotics, high-dose corticosteroids and mechanical ventilation, he expired on the 5th hospital day. Here, we report the case of P. jiroveci pneumonia in a boy with agammaglobulinemia.
Key Words: humoral immunity; immunodeficiency; Pneumocystis jiroveci; X-linked agammaglobulinemia
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