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Original Article
- Epidemiology
- Outcomes of extracorporeal membrane oxygenation support in pediatric hemato-oncology patients
- Hong Yul An, Hyoung Jin Kang, June Dong Park
- Acute Crit Care. 2024;39(1):108-116. Published online January 24, 2024
- DOI: https://doi.org/10.4266/acc.2023.01088
- 6,378 View
- 201 Download
- 2 Web of Science
- 4 Crossref
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Abstract
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Supplementary Material - Background
In this study, we reviewed the outcomes of pediatric patients with malignancies who underwent hematopoietic stem cell transplantation (HSCT) and extracorporeal membrane oxygenation (ECMO).
Methods
We retrospectively analyzed the records of pediatric hemato-oncology patients treated with chemotherapy or HSCT and who received ECMO in the pediatric intensive care unit (PICU) at Seoul National University Children’s Hospital from January 2012 to December 2020.
Results
Over a 9-year period, 21 patients (14 males and 7 females) received ECMO at a single pediatric institute; 10 patients (48%) received veno-arterial (VA) ECMO for septic shock (n=5), acute respiratory distress syndrome (ARDS) (n=3), stress-induced myopathy (n=1), or hepatopulmonary syndrome (n=1); and 11 patients (52%) received veno-venous (VV) ECMO for ARDS due to pneumocystis pneumonia (n=1), air leak (n=3), influenza (n=1), pulmonary hemorrhage (n=1), or unknown etiology (n=5). All patients received chemotherapy; 9 received anthracycline drugs and 14 (67%) underwent HSCT. Thirteen patients (62%) were diagnosed with malignancies and 8 (38%) were diagnosed with non-malignant disease. Among the 21 patients, 6 (29%) survived ECMO in the PICU and 5 (24%) survived to hospital discharge. Among patients treated for septic shock, 3 of 5 patients (60%) who underwent ECMO and 5 of 10 patients (50%) who underwent VA ECMO survived. However, all the patients who underwent VA ECMO or VV ECMO for ARDS died.
Conclusions
ECMO is a feasible treatment option for respiratory or heart failure in pediatric patients receiving chemotherapy or undergoing HSCT. -
Citations
Citations to this article as recorded by
- Successful ECMO in an immunocompromised child with ALL, sepsis, and pneumonia
Radoslaw Jaworski, Anna Małecka, Jakub Brzeziński, Tomasz Lammek, Romuald Lango, Ninela Irga‐Jaworska
Pediatrics International.2026;[Epub] CrossRef - Extracorporeal Membrane Oxygenation in Pediatric Severe Aplastic Anemia: A Case Report Highlighting Risk-Benefit and Ethical Considerations
Abigail S Abraham, Merin M Mathew, Lyndsey Thomas, John Abraham, Madhura Butala
Cureus.2026;[Epub] CrossRef - Extracorporeal Membrane Oxygenation in the Management of Tumor Lysis Syndrome in Children: A Review of Cases
Zere Aidynbek, Erken Kakenov, Olga Mironova, Karlygash Ydyrysheva, Tatyana Li, Vitaliy Sazonov
Journal of Clinical Medicine.2025; 14(8): 2771. CrossRef - Successful venoarterial extracorporeal membrane oxygenation support for septic shock in a child with relapsed acute myeloid leukemia and complete superior vena cava obstruction: a case report
Bo Ram Kim, Hwa Jin Cho, Insu Choi, Hee Jo Baek, Hoon Kook, In Seok Jeong
Archives of Pediatric Critical Care.2025; 3(2): 89. CrossRef
- Successful ECMO in an immunocompromised child with ALL, sepsis, and pneumonia
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