It is well known that cardiac dysfunction in sepsis is associated with significantly increased mortality. The pathophysiology of sepsis-induced cardiac dysfunction can be summarized as involving impaired myocardial circulation, direct myocardial depression, and mitochondrial dysfunction. Impaired blood flow to the myocardium is associated with microvascular dysfunction, impaired endothelium, and ventriculo-arterial uncoupling. The mechanisms behind direct myocardial depression consist of downregulation of β-adrenoceptors and several myocardial suppressants (such as cytokine and nitric oxide). Recent research has highlighted that mitochondrial dysfunction, which results in energy depletion, is a major factor in sepsis-induced cardiac dysfunction. Therefore, the authors summarize the pathophysiological process of cardiac dysfunction in sepsis based on the results of recent studies.
Citations
Citations to this article as recorded by
Neonatal sepsis and cardiovascular dysfunction I: mechanisms and pathophysiology Sophie M. Duignan, Satyan Lakshminrusimha, Kathryn Armstrong, Willem P. de Boode, Afif El-Khuffash, Orla Franklin, Eleanor J. Molloy, Willem P. de Boode, Franz B. Plötz, Tobias Strunk, Marina Degtyareva, Helmut Küster, Eric Giannoni, Joseph M. Bliss, H. R Pediatric Research.2024; 95(5): 1207. CrossRef
6-Gingerol, an ingredient of Zingiber officinale, abrogates lipopolysaccharide-induced cardiomyocyte injury by reducing oxidative stress and inflammation Azar Hosseini, Mohaddeseh Sadat Alavi, Mitra Ghane Nikookar Toos, Tannaz Jamialahmadi, Amirhossein Sahebkar Journal of Agriculture and Food Research.2024; 15: 101034. CrossRef
Inflammation and arrhythmogenesis: a narrative review of the complex relationship Andia Taghdiri International Journal of Arrhythmia.2024;[Epub] CrossRef
Inotropic drugs in septic shock Nutnicha Yolsiriwat, Surat Tongyoo Clinical Critical Care.2024;[Epub] CrossRef
Epigallocatechin-3-gallate protects sepsis‐induced myocardial dysfunction by inhibiting the nuclear factor-κB signaling pathway Bei Chen, Ya-Fei Li, Zhang Fang, Wen-Yi Cai, Zhi-Qiang Tian, Dianfu Li, Ze-Mu Wang Heliyon.2024; 10(5): e27163. CrossRef
Myocardial Injury as a Harbinger of Multi-organ Failure in Septic Shock: A Comprehensive Review Amol Singam Cureus.2024;[Epub] CrossRef
Case 9-2024: An 84-Year-Old Man with a Fall Richard C. Cabot, Eric S. Rosenberg, David M. Dudzinski, Meridale V. Baggett, Kathy M. Tran, Dennis C. Sgroi, Jo-Anne O. Shepard, Emily K. McDonald, Tara Corpuz, Zaven Sargsyan, Sunita D. Srivastava, Virginia A. Triant, Brian B. Ghoshhajra New England Journal of Medicine.2024; 390(12): 1129. CrossRef
Melatonin: A potential protective multifaceted force for sepsis-induced cardiomyopathy Eman Casper, Lamia El Wakeel, Nagwa Sabri, Ramy Khorshid, Sarah F. Fahmy Life Sciences.2024; 346: 122611. CrossRef
Hemodynamic goals in sepsis and septic shock resuscitation: An umbrella review of systematic reviews and meta-analyses with trial sequential analysis Daniele Orso, Nicola Federici, Cristina Lio, Filippo Mearelli, Tiziana Bove Australian Critical Care.2024;[Epub] CrossRef
A case of sepsis‐induced cardiomyopathy successfully treated with venoarterial extracorporeal membrane oxygenation Keigo Sato, Akihiro Naito, Taichi Shiratori, Masahiro Yamamoto, Kenichi Shimane, Manabu Mikami, Mariko Senda, Haruki Kume, Motofumi Suzuki IJU Case Reports.2023; 6(1): 26. CrossRef
Jujuboside A attenuates sepsis-induced cardiomyopathy by inhibiting inflammation and regulating autophagy Zi Wang, Danrui Xiao, Qingqi Ji, Yanjie Li, Zhaohua Cai, Liang Fang, Huanhuan Huo, Guo Zhou, Xiangming Yan, Linghong Shen, Ben He European Journal of Pharmacology.2023; 947: 175451. CrossRef
Mitochondrial transplantation protects against sepsis-induced myocardial dysfunction by modulating mitochondrial biogenesis and fission/fusion and inflammatory response Behnaz Mokhtari, Masoud Hamidi, Reza Badalzadeh, Ata Mahmoodpoor Molecular Biology Reports.2023; 50(3): 2147. CrossRef
Therapeutic potentials of stem cell–derived exosomes in cardiovascular diseases Saiprahalad Mani, Narasimman Gurusamy, Thennavan Ulaganathan, Autumn J Paluck, Satish Ramalingam, Johnson Rajasingh Experimental Biology and Medicine.2023; 248(5): 434. CrossRef
CLINICAL, MOLECULAR, AND EXOSOMAL MECHANISMS OF CARDIAC AND BRAIN DYSFUNCTION IN SEPSIS Daniel C. Morris, Zheng Gang Zhang, Anja K. Jaehne, Jing Zhang, Emanuel P. Rivers Shock.2023; 59(2): 173. CrossRef
Circulating protein and lipid markers of early sepsis diagnosis and prognosis: a scoping review Gemma Barber, Jelena Tanic, Aleksandra Leligdowicz Current Opinion in Lipidology.2023; 34(2): 70. CrossRef
Extracellular Histone-Induced Protein Kinase C Alpha Activation and Troponin Phosphorylation Is a Potential Mechanism of Cardiac Contractility Depression in Sepsis Simon T. Abrams, Yasir Alhamdi, Min Zi, Fengmei Guo, Min Du, Guozheng Wang, Elizabeth J. Cartwright, Cheng-Hock Toh International Journal of Molecular Sciences.2023; 24(4): 3225. CrossRef
Septic cardiomyopathy: A narrative review Maria Rita Lima, Doroteia Silva Revista Portuguesa de Cardiologia.2023; 42(5): 471. CrossRef
Enfoque de la miocardiopatía séptica como causa de choque refractario en escenarios de recursos limitados: reporte de caso Liliana Correa-Pérez, Diana Carolina Otálora Álvarez, Gloria Camila Álvarez Gallego Acta Colombiana de Cuidado Intensivo.2023; 23(3): 303. CrossRef
Role of Pellino-1 in Inflammation and Cardioprotection following Severe Sepsis: A Novel Mechanism in a Murine Severe Sepsis Model † Mahesh Thirunavukkarasu, Santosh Swaminathan, Andrew Kemerley, Seetur R. Pradeep, Sue Ting Lim, Diego Accorsi, Rickesha Wilson, Jacob Campbell, Ibnalwalid Saad, Siu-Pok Yee, J. Alexander Palesty, David W. McFadden, Nilanjana Maulik Cells.2023; 12(11): 1527. CrossRef
circHIPK3 exacerbates sepsis-induced acute kidney injury and cardiopulmonary function by regulating microRNA-106a-5p/ROCK2 axis Heng Li, Lingkai Kang, Jianglu Tan, Wanli Li, Dongrui He, Jing Han, Jie Zhang, Yulin Guan, Ying Huang, Xiaoyue Li Process Biochemistry.2023; 131: 272. CrossRef
Estradiol as the Trigger of Sirtuin-1-Dependent Cell Signaling with a Potential Utility in Anti-Aging Therapies Kamil Karolczak, Cezary Watala International Journal of Molecular Sciences.2023; 24(18): 13753. CrossRef
Baricitinib protects mice from sepsis-induced cardiac dysfunction and multiple-organ failure Chiara Verra, Shireen Mohammad, Gustavo Ferreira Alves, Elisa Porchietto, Sina Maren Coldewey, Massimo Collino, Christoph Thiemermann Frontiers in Immunology.2023;[Epub] CrossRef
Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction Gabriel Jakobsson, Praveen Papareddy, Henrik Andersson, Megan Mulholland, Ravi Bhongir, Irena Ljungcrantz, Daniel Engelbertsen, Harry Björkbacka, Jan Nilsson, Adrian Manea, Heiko Herwald, Marisol Ruiz-Meana, Antonio Rodríguez-Sinovas, Michelle Chew, Alexa Critical Care.2023;[Epub] CrossRef
Cardiac troponin as a prognosticator of mortality in patients with sepsis: A systematic review and meta‐analysis Peiqiu Zheng, Xing Wang, Tao Guo, Wei Gao, Qiang Huang, Jie Yang, Hui Gao, Qian Liu Immunity, Inflammation and Disease.2023;[Epub] CrossRef
Decoding molecular signature on heart of septic mice with distinct left ventricular ejection fraction Lina Zhang, Desheng Qi, Milin Peng, Binbin Meng, Xinrun Wang, Xiaolei Zhang, Zhihong Zuo, Li Li, Zhanwen Wang, Wenxuan Zou, Zhonghua Hu, Zhaoxin Qian iScience.2023; 26(10): 107825. CrossRef
Role of toll-like receptor-mediated pyroptosis in sepsis-induced cardiomyopathy Yixuan Fan, Baoyi Guan, Jianxing Xu, He Zhang, Liang Yi, Zhixu Yang Biomedicine & Pharmacotherapy.2023; 167: 115493. CrossRef
Understanding yellow fever-associated myocardial injury: an autopsy study Fernando Rabioglio Giugni, Vera Demarchi Aiello, Caroline Silverio Faria, Shahab Zaki Pour, Marielton dos Passos Cunha, Melina Valdo Giugni, Henrique Trombini Pinesi, Felipe Lourenço Ledesma, Carolina Esteves Morais, Yeh-Li Ho, Jaques Sztajnbok, Sandra de eBioMedicine.2023; 96: 104810. CrossRef
The role of beta-blocker drugs in critically ill patients: a SIAARTI expert consensus statement Fabio Guarracino, Andrea Cortegiani, Massimo Antonelli, Astrid Behr, Giandomenico Biancofiore, Alfredo Del Gaudio, Francesco Forfori, Nicola Galdieri, Giacomo Grasselli, Gianluca Paternoster, Monica Rocco, Stefano Romagnoli, Salvatore Sardo, Sascha Treska Journal of Anesthesia, Analgesia and Critical Care.2023;[Epub] CrossRef
Sedation for Patients with Sepsis: Towards a Personalised Approach José Miguel Marcos-Vidal, Rafael González, María Merino, Eva Higuera, Cristina García Journal of Personalized Medicine.2023; 13(12): 1641. CrossRef
High serum nitrates levels in non-survivor COVID-19 patients L. Lorente, F. Gómez-Bernal, M.M. Martín, J.A. Navarro-Gonzálvez, M. Argueso, A. Perez, L. Ramos-Gómez, J. Solé-Violán, J.A. Marcos y Ramos, N. Ojeda, A. Jiménez Medicina Intensiva.2022; 46(3): 132. CrossRef
Vital signs as physiomarkers of neonatal sepsis Brynne A. Sullivan, Karen D. Fairchild Pediatric Research.2022; 91(2): 273. CrossRef
Fluid therapy for severe malaria Laura C Kalkman, Thomas Hänscheid, Sanjeev Krishna, Martin P Grobusch The Lancet Infectious Diseases.2022; 22(6): e160. CrossRef
High serum nitrates levels in non-survivor COVID-19 patients L. Lorente, F. Gómez-Bernal, M.M. Martín, J.A. Navarro-Gonzálvez, M. Argueso, A. Perez, L. Ramos-Gómez, J. Solé-Violán, J.A. Marcos y Ramos, N. Ojeda, A. Jiménez Medicina Intensiva (English Edition).2022; 46(3): 132. CrossRef
Expression of Peripheral Blood DCs CD86, CD80, and Th1/Th2 in Sepsis Patients and Their Value on Survival Prediction Ke Du, Shaobo Hao, Heyun Luan, Min Tang Computational and Mathematical Methods in Medicine.2022; 2022: 1. CrossRef
Recombinant Activated Protein C (rhAPC) Affects Lipopolysaccharide-Induced Mechanical Compliance Changes and Beat Frequency of mESC-Derived Cardiomyocyte Monolayers Aysegül Temiz Artmann, Eylem Kurulgan Demirci, Ipek Seda Fırat, Hakan Oflaz, Gerhard M. Artmann Shock.2022; 57(4): 544. CrossRef
Acute cholecystitis associated with sepsis-induced ischemic cardiomyopathy Ke-Shiuan Ju, Ying-Shih Su, Wen-Sen Lee Journal of Infection.2022; 84(6): 834. CrossRef
An Overview on Mitochondrial-Based Therapies in Sepsis-Related Myocardial Dysfunction: Mitochondrial Transplantation as a Promising Approach Behnaz Mokhtari, Rana Yavari, Reza Badalzadeh, Ata Mahmoodpoor, Jayaraman Tharmalingam Canadian Journal of Infectious Diseases and Medical Microbiology.2022; 2022: 1. CrossRef
Pathological role of the calcium‐sensing receptor in sepsis‐induced hypotensive shock: Therapeutic possibilities and unanswered questions Ankita Sood, Gaaminepreet Singh, Thakur G. Singh, Kirti Gupta Drug Development Research.2022; 83(6): 1241. CrossRef
Diminazene aceturate mitigates cardiomyopathy by interfering with renin-angiotensin system in a septic rat model Zhaoqing Lu, Di Wu, Zheng Wang, Hanyu Zhang, Yufan Du, Guoxing Wang BMC Pharmacology and Toxicology.2022;[Epub] CrossRef
Serum Sestrin2 Was Lower in Septic Shock Patients with Cardiomyopathy Rongjin Huang, Feng Chen, Aiying Zeng, Jun Ke, Shirong Lin, QiXing Chen Disease Markers.2022; 2022: 1. CrossRef
Tidy up - The unfolded protein response in sepsis Wolfgang Vivas, Sebastian Weis Frontiers in Immunology.2022;[Epub] CrossRef
DAMPs Released from Proinflammatory Macrophages Induce Inflammation in Cardiomyocytes via Activation of TLR4 and TNFR Carolina Neu, Yvonne Thiele, Fabienne Horr, Christian Beckers, Nadine Frank, Gernot Marx, Lukas Martin, Sandra Kraemer, Elisabeth Zechendorf International Journal of Molecular Sciences.2022; 23(24): 15522. CrossRef
Targeting the TXNIP‐NLRP3 interaction with PSSM1443 to suppress inflammation in sepsis‐induced myocardial dysfunction Linhua Wang, Hongsheng Zhao, Huifen Xu, Xiangxin Liu, Xinlong Chen, Qingyun Peng, Mingbing Xiao Journal of Cellular Physiology.2021; 236(6): 4625. CrossRef
Sepsis—Pathophysiology and Therapeutic Concepts Dominik Jarczak, Stefan Kluge, Axel Nierhaus Frontiers in Medicine.2021;[Epub] CrossRef
Rho-Proteins and Downstream Pathways as Potential Targets in Sepsis and Septic Shock: What Have We Learned from Basic Research Maria Luísa da Silveira Hahmeyer, José Eduardo da Silva-Santos Cells.2021; 10(8): 1844. CrossRef
Deep-learning model for screening sepsis using electrocardiography Joon-myoung Kwon, Ye Rang Lee, Min-Seung Jung, Yoon-Ji Lee, Yong-Yeon Jo, Da-Young Kang, Soo Youn Lee, Yong-Hyeon Cho, Jae-Hyun Shin, Jang-Hyeon Ban, Kyung-Hee Kim Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine.2021;[Epub] CrossRef
Levosimendan versus dobutamine for sepsis-induced cardiac dysfunction: a systematic review and meta-analysis Dong-Hua Liu, Yi-Le Ning, Yan-Yan Lei, Jing Chen, Yan-Yan Liu, Xin-Feng Lin, Zhong-Qi Yang, Shao-Xiang Xian, Wei-Tao Chen Scientific Reports.2021;[Epub] CrossRef
Exosomes Derived from miR-146a-5p-Enriched Mesenchymal Stem Cells Protect the Cardiomyocytes and Myocardial Tissues in the Polymicrobial Sepsis through Regulating MYBL1 Chun Liu, Jianhua Xue, Bo Xu, Aixian Zhang, Lili Qin, Jiajia Liu, Yang Yang, Antonio C. Campos de Carvalho Stem Cells International.2021; 2021: 1. CrossRef
Mitochondria are considered the power house of the cell and are an essential part of the cellular infrastructure, serving as the primary site for adenosine triphosphate production via oxidative phosphorylation. These organelles also release reactive oxygen species (ROS), which are normal byproducts of metabolism at physiological levels; however, overproduction of ROS under pathophysiological conditions is considered part of a disease process, as in sepsis. The inflammatory response inherent in sepsis initiates changes in normal mitochondrial functions that may result in organ damage. There is a complex system of interacting antioxidant defenses that normally function to combat oxidative stress and prevent damage to the mitochondria. It is widely accepted that oxidative stress-mediated injury plays an important role in the development of organ failure; however, conclusive evidence of any beneficial effect of systemic antioxidant supplementation in patients with sepsis and organ dysfunction is lacking. Nevertheless, it has been suggested that antioxidant therapy delivered specifically to the mitochondria may be useful.
Citations
Citations to this article as recorded by
Oxidative Stress in Sepsis: A Focus on Cardiac Pathology Giuseppe Bertozzi, Michela Ferrara, Aldo Di Fazio, Aniello Maiese, Giuseppe Delogu, Nicola Di Fazio, Vittoria Tortorella, Raffaele La Russa, Vittorio Fineschi International Journal of Molecular Sciences.2024; 25(5): 2912. CrossRef
Proteome characterization of liver–kidney comorbidity after microbial sepsis Yuan Gui, Yanbao Yu, Wenjia Wang, Yuanyuan Wang, Hanyue Lu, Sarah Mozdzierz, Kirollos Eskander, Yi‐Han Lin, Hanwen Li, Xiao‐Jun Tian, Silvia Liu, Dong Zhou The FASEB Journal.2024;[Epub] CrossRef
Macrophages-regulating nanomedicines for sepsis therapy Jiali Deng, Rui Wang, Shu Huang, Jinsong Ding, Wenhu Zhou Chinese Chemical Letters.2023; 34(3): 107588. CrossRef
Protective effect of melatonin and ascorbic acid combination on sepsis‐induced lung injury: An Experimental study Hilal Üstündağ, Özlem Demir, Betül Çiçek, Mehmet Tahir Huyut, Neslihan Yüce, Taha Tavacı Clinical and Experimental Pharmacology and Physiology.2023; 50(8): 634. CrossRef
Sepsis-induced mitochondrial dysfunction: A narrative review Wagner Nedel, Caroline Deutschendorf, Luis Valmor Cruz Portela World Journal of Critical Care Medicine.2023; 12(3): 139. CrossRef
Oxidative stress and DNA damage in critically ill patients with sepsis Olgica Mihaljevic, Snezana Zivancevic-Simonovic, Danijela Jovanovic, Svetlana Miletic Drakulic, Jovana Tubic Vukajlovic, Aleksandra Markovic, Marijana Stanojevic Pirkovic, Ivan Srejovic, Vladimir Jakovljevic, Olivera Milosevic-Djordjevic Mutation Research/Genetic Toxicology and Environmental Mutagenesis.2023; 889: 503655. CrossRef
A comprehensive insight into the molecular and cellular mechanisms of action of resveratrol on complications of sepsis a systematic review Mahdi Vajdi, Pouria Sefidmooye Azar, Ata Mahmoodpoor, Farzaneh Dashti, Sarvin Sanaie, Fateme Kiani Chalmardi, Arash Karimi Phytotherapy Research.2023; 37(9): 3780. CrossRef
Significance of sTREM-1 and sST2 combined diagnosis for sepsis detection and prognosis prediction Yongjun Wei, Ping Xiao, Benjuan Wu, Fuxi Chen, Xiaofeng Shi Open Life Sciences.2023;[Epub] CrossRef
Gossypol improves myocardial dysfunction caused by sepsis by regulating histone acetylation Xiaohui Shi, Xinwei Lv, Dong Xiao Clinical and Translational Science.2023; 16(11): 2189. CrossRef
The Anti-Oxidative, Anti-Inflammatory, Anti-Apoptotic, and Anti-Necroptotic Role of Zinc in COVID-19 and Sepsis George Briassoulis, Panagiotis Briassoulis, Stavroula Ilia, Marianna Miliaraki, Efrossini Briassouli Antioxidants.2023; 12(11): 1942. CrossRef
Understanding Post-Sepsis Syndrome: How Can Clinicians Help? Elisabeth C van der Slikke, Lise FE Beumeler, Madlene Holmqvist, Adam Linder, Robert T Mankowski, Hjalmar R Bouma Infection and Drug Resistance.2023; Volume 16: 6493. CrossRef
Inflammation-responsive drug delivery nanosystems for treatment of bacterial-induced sepsis Vincent O. Nyandoro, Calvin A. Omolo, Eman A. Ismail, Liu Yong, Thirumala Govender International Journal of Pharmaceutics.2023; 644: 123346. CrossRef
Restoring the infected powerhouse: Mitochondrial quality control in sepsis F.M. Lira Chavez, L.P. Gartzke, F.E. van Beuningen, S.E. Wink, R.H. Henning, G. Krenning, H.R. Bouma Redox Biology.2023; 68: 102968. CrossRef
Polymeric Particle BAM15 Targeting Macrophages Attenuates the Severity of LPS-Induced Sepsis: A Proof of Concept for Specific Immune Cell-Targeted Therapy Kanyarat Udompornpitak, Thansita Bhunyakarnjanarat, Wilasinee Saisorn, Chonnavee Manipuntee, Kittawat Plengplang, Samarch Sittichaitaweekul, Panisa Jenphatanapong, Suwasin Udomkarnjananun, Warerat Kaewduangduen, Kasirapat Ariya-anandech, Amanee Samaeng, N Pharmaceutics.2023; 15(12): 2695. CrossRef
Impact of norepinephrine on immunity and oxidative metabolism in sepsis Joby Thoppil, Prayag Mehta, Brett Bartels, Drashya Sharma, J. David Farrar Frontiers in Immunology.2023;[Epub] CrossRef
A pilot study on the melatonin treatment in patients with early septic shock: results of a single-center randomized controlled trial Abbas Taher, Farnaz Shokoohmand, Elham Abdoli, Younes Mohammadi, Maryam Mehrpooya Irish Journal of Medical Science (1971 -).2022; 191(4): 1913. CrossRef
Biomarker Analysis for Combination Therapy of Vitamin C and Thiamine in Septic Shock: A Post-Hoc Study of the ATESS Trial Jong Eun Park, You Hwan Jo, Sung Yeon Hwang, Won Young Kim, Seung Mok Ryoo, Dong-Hyun Jang, Taegyun Kim, Youn-Jung Kim, Seonwoo Kim, Hyun Cho, Gun Tak Lee, Sung Phil Chung, Sung-Hyuk Choi, Tae Gun Shin, Gil Joon Suh Shock.2022; 57(1): 81. CrossRef
Anagliptin prevents lipopolysaccharide (LPS)- induced inflammation and activation of macrophages Fangfang Yu, Wenxia Tian, Jie Dong International Immunopharmacology.2022; 104: 108514. CrossRef
Pink1/Parkin-Mediated Mitophagy Regulated the Apoptosis of Dendritic Cells in Sepsis Yaolu Zhang, Longwang Chen, Yinan Luo, Kang Wang, Xinyong Liu, Zhong Xiao, Guangju Zhao, Yongming Yao, Zhongqiu Lu Inflammation.2022; 45(3): 1374. CrossRef
Inhibition of mitoNEET attenuates LPS-induced inflammation and oxidative stress Seunghee Lee, Byeong Geun Seok, Seon-Jin Lee, Su Wol Chung Cell Death & Disease.2022;[Epub] CrossRef
An update in the utilization of N-acetyl cysteine & vitamin c for tackling the oxidative stress in acute kidney injury secondary to robust sepsis - A systematic review Kaur Kulvinder Kochar, Allahbadia Gautam, Singh Mandeep Journal of Clinical Nephrology.2022; 6(1): 001. CrossRef
Mitochondrial Protein Akap1 Deletion Exacerbates Endoplasmic Reticulum Stress in Mice Exposed to Hyperoxia Sahebgowda Sidramagowda Patil, Ramani Soundararajan, Jutaro Fukumoto, Mason Breitzig, Helena Hernández-Cuervo, Matthew Alleyn, Muling Lin, Venkata Ramireddy Narala, Richard Lockey, Narasaiah Kolliputi, Lakshmi Galam Frontiers in Pharmacology.2022;[Epub] CrossRef
COVID-19, Oxidative Stress, and Neuroinflammation in the Depression Route Maiqueli Eduarda Dama Mingoti, Amanda Gollo Bertollo, Júlia Leão Batista Simões, Gabriel Rossi Francisco, Margarete Dulce Bagatini, Zuleide Maria Ignácio Journal of Molecular Neuroscience.2022; 72(6): 1166. CrossRef
Low-power infrared laser modulates mRNA levels from genes of base excision repair and genomic stabilization in heart tissue from an experimental model of acute lung injury Larissa Alexsandra da Silva Neto Trajano, Luiz Philippe da Silva Sergio, Diego Sá Leal de Oliveira, Eduardo Tavares Lima Trajano, Marco Aurélio dos Santos Silva, Flávia de Paoli, André Luiz Mencalha, Adenilson de Souza da Fonseca Photochemical & Photobiological Sciences.2022; 21(7): 1299. CrossRef
Landscape of Metabolic Fingerprinting for Diagnosis and Risk Stratification of Sepsis Geng Lu, Jiawei Zhou, Ting Yang, Jin Li, Xinrui Jiang, Wenjun Zhang, Shuangshuang Gu, Jun Wang Frontiers in Immunology.2022;[Epub] CrossRef
Nano-curcumin supplementation in critically ill patients with sepsis: a randomized clinical trial investigating the inflammatory biomarkers, oxidative stress indices, endothelial function, clinical outcomes and nutritional status Arash Karimi, Fatemeh Naeini, Hamid Reza Niazkar, Helda Tutunchi, Vali Musazadeh, Ata Mahmoodpoor, Vahid Asghariazar, Majid Mobasseri, Ali Tarighat-Esfanjani Food & Function.2022; 13(12): 6596. CrossRef
An Overview on Mitochondrial-Based Therapies in Sepsis-Related Myocardial Dysfunction: Mitochondrial Transplantation as a Promising Approach Behnaz Mokhtari, Rana Yavari, Reza Badalzadeh, Ata Mahmoodpoor, Jayaraman Tharmalingam Canadian Journal of Infectious Diseases and Medical Microbiology.2022; 2022: 1. CrossRef
p66Shc in Cardiovascular Pathology Landon Haslem, Jennifer M. Hays, Franklin A. Hays Cells.2022; 11(11): 1855. CrossRef
Ablation of long noncoding RNA MALAT1 activates antioxidant pathway and alleviates sepsis in mice Jingshu Chen, Shu Tang, Sui Ke, James J. Cai, Daniel Osorio, Andrei Golovko, Benjamin Morpurgo, Shaodong Guo, Yuxiang Sun, Melanie Winkle, George A. Calin, Yanan Tian Redox Biology.2022; 54: 102377. CrossRef
Comparison enteral superoxide dismutase 1 IU and 5 IU from Cucumis melo L.C extract combined with gliadin as an antioxidant and anti-inflammatory in LPS-Induced sepsis model rats Cut Meliza Zainumi, Gontar Alamsyah Siregar, Dadik Wahyu Wijaya, Muhammad Ichwan Heliyon.2022; 8(8): e10236. CrossRef
Evidence-based updates to the 2021 Surviving Sepsis Campaign guidelines Karen D. Lehman The Nurse Practitioner.2022; 47(11): 24. CrossRef
Stimuli-responsive and biomimetic delivery systems for sepsis and related complications Eman A. Ismail, Nikita Devnarain, Thirumala Govender, Calvin A. Omolo Journal of Controlled Release.2022; 352: 1048. CrossRef
P66Shc (Shc1) Zebrafish Mutant Line as a Platform for Testing Decreased Reactive Oxygen Species in Pathology Landon Haslem, Jennifer M. Hays, Xin A. Zhang, Franklin A. Hays Journal of Cardiovascular Development and Disease.2022; 9(11): 385. CrossRef
Low dimensional nanomaterials for treating acute kidney injury Yuanpeng Nie, Liying Wang, Xinru You, Xiaohua Wang, Jun Wu, Zhihua Zheng Journal of Nanobiotechnology.2022;[Epub] CrossRef
Hydroxytyrosol ameliorates oxidative challenge and inflammatory response associated with lipopolysaccharide-mediated sepsis in mice Mohamed A Alblihed Human & Experimental Toxicology.2021; 40(2): 342. CrossRef
Advances in sepsis diagnosis and management: a paradigm shift towards nanotechnology Amit Pant, Irene Mackraj, Thirumala Govender Journal of Biomedical Science.2021;[Epub] CrossRef
Targeting the TXNIP‐NLRP3 interaction with PSSM1443 to suppress inflammation in sepsis‐induced myocardial dysfunction Linhua Wang, Hongsheng Zhao, Huifen Xu, Xiangxin Liu, Xinlong Chen, Qingyun Peng, Mingbing Xiao Journal of Cellular Physiology.2021; 236(6): 4625. CrossRef
Mitochondrial gene mutations in pediatric septic shock Junsung Park, Eunju Kang, Seoon Kang, Deokhoon Kim, Dahyun Kim, Seong Jong Park, Won Kyoung Jhang Pediatric Research.2021; 90(5): 1016. CrossRef
Polymeric Antioxidant Materials for Treatment of Inflammatory Disorders Jiwon Yeo, Junseok Lee, Sanggi Lee, Won Jong Kim Advanced Therapeutics.2021;[Epub] CrossRef
Pathophysiology of sepsis Pietro Arina, Mervyn Singer Current Opinion in Anaesthesiology.2021; 34(2): 77. CrossRef
Oxidative Stress and Endothelial Dysfunction in Sepsis and Acute Inflammation Jérémie Joffre, Judith Hellman Antioxidants & Redox Signaling.2021; 35(15): 1291. CrossRef
The Prospects of Succinates’ Use under Hypoxic Conditions in COVID-19 Yu. Р. Orlov, V. V. Afanasyev, I. A. Khilenko Antibiotics and Chemotherapy.2021; 66(1-2): 65. CrossRef
On the Possibility of Using Succinate in Hypoxia Developing in COVID-19 Yu. P. Orlov, N. V. Govorova, O. V. Korpacheva, V. V. Afanasyev, I. A. Khilenko General Reanimatology.2021; 17(3): 78. CrossRef
Sepsis: Evidence-based pathogenesis and treatment Jay Pravda World Journal of Critical Care Medicine.2021; 10(4): 66. CrossRef
Albumin Oxidation Status in Sepsis Patients Treated With Albumin or Crystalloids Matteo Bonifazi, Jennifer Meessen, Alba Pérez, Francesco Vasques, Mattia Busana, Francesco Vassalli, Deborah Novelli, Roberto Bernasconi, Chiara Signori, Serge Masson, Federica Romitti, Lorenzo Giosa, Matteo Macrì, Iacopo Pasticci, Maria Michela Palumbo, Frontiers in Physiology.2021;[Epub] CrossRef
Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19 Neven Žarković, Biserka Orehovec, Lidija Milković, Bruno Baršić, Franz Tatzber, Willibald Wonisch, Marko Tarle, Marta Kmet, Ana Mataić, Antonia Jakovčević, Tea Vuković, Danijela Talić, Georg Waeg, Ivica Lukšić, Elzbieta Skrzydlewska, Kamelija Žarković Antioxidants.2021; 10(9): 1341. CrossRef
Targeting Oxidative Stress in Septic Acute Kidney Injury: From Theory to Practice Connie P. C. Ow, Anton Trask-Marino, Ashenafi H. Betrie, Roger G. Evans, Clive N. May, Yugeesh R. Lankadeva Journal of Clinical Medicine.2021; 10(17): 3798. CrossRef
The Effects of a Meldonium Pre-Treatment on the Course of the Faecal-Induced Sepsis in Rats Siniša Đurašević, Aleksandra Ružičić, Iva Lakić, Tomislav Tosti, Saša Đurović, Sofija Glumac, Slađan Pavlović, Slavica Borković-Mitić, Ilijana Grigorov, Sanja Stanković, Nebojša Jasnić, Jelena Đorđević, Zoran Todorović International Journal of Molecular Sciences.2021; 22(18): 9698. CrossRef
TRP Channels as Sensors of Aldehyde and Oxidative Stress Katharina E. M. Hellenthal, Laura Brabenec, Eric R. Gross, Nana-Maria Wagner Biomolecules.2021; 11(10): 1401. CrossRef
Intramuscular Exposure to a Lethal Dose of Ricin Toxin Leads to Endothelial Glycocalyx Shedding and Microvascular Flow Abnormality in Mice and Swine Anita Sapoznikov, Yoav Gal, Yentl Evgy, Moshe Aftalion, Shahaf Katalan, Tamar Sabo, Chanoch Kronman, Reut Falach International Journal of Molecular Sciences.2021; 22(22): 12345. CrossRef
LBP Protects Hepatocyte Mitochondrial Function Via the PPAR-CYP4A2 Signaling Pathway in a Rat Sepsis Model Zichen Song, Leilei Meng, Zhixiang He, Jing Huang, Fang Li, Jingjing Feng, Zhuoran Jia, Yue Huang, Wei Liu, Anding Liu, Haoshu Fang Shock.2021; 56(6): 1066. CrossRef
Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention Valery Danilenko, Andrey Devyatkin, Mariya Marsova, Madina Shibilova, Rustem Ilyasov, Vladimir Shmyrev Journal of Inflammation Research.2021; Volume 14: 6349. CrossRef
ALKBH8 Suppresses Oxidative Stress and Ameliorates Inflammation via Blocking NFκB/NLRP3 Axis in Sepsis Ni Yang, Li Zhang, Junhua Lv, Zequn Niu, Jie Liu, Ping Li, Zhengliang Zhang SSRN Electronic Journal .2021;[Epub] CrossRef
Immunomodulatory Effect of Doxycycline Ameliorates Systemic and Pulmonary Inflammation in a Murine Polymicrobial Sepsis Model Anasuya Patel, Hemant Khande, Hariharan Periasamy, Santosh Mokale Inflammation.2020; 43(3): 1035. CrossRef
Agaricus brasiliensis Mushroom Protects Against Sepsis by Alleviating Oxidative and Inflammatory Response Kely Campos Navegantes-Lima, Valter Vinicius Silva Monteiro, Silvia Leticia de França Gaspar, Ana Ligia de Brito Oliveira, Juliana Pinheiro de Oliveira, Jordano Ferreira Reis, Rafaelli de Souza Gomes, Caroline Azulay Rodrigues, Herta Stutz, Vanessa Sovran Frontiers in Immunology.2020;[Epub] CrossRef
Oxidative Stress and Inflammation in COVID-19-Associated Sepsis: The Potential Role of Anti-Oxidant Therapy in Avoiding Disease Progression Jesús Beltrán-García, Rebeca Osca-Verdegal, Federico V. Pallardó, José Ferreres, María Rodríguez, Sandra Mulet, Fabian Sanchis-Gomar, Nieves Carbonell, José Luis García-Giménez Antioxidants.2020; 9(10): 936. CrossRef
Molecular mechanisms of organ damage in sepsis: an overview Grażyna Sygitowicz, Dariusz Sitkiewicz The Brazilian Journal of Infectious Diseases.2020; 24(6): 552. CrossRef
Mitochondrial dysfunction in critical illness during acute metabolic stress and convalescence: consequences for nutrition therapy Hanneke Pierre Franciscus Xaverius Moonen, Arthur Raymond Hubert Van Zanten Current Opinion in Critical Care.2020; 26(4): 346. CrossRef
Azithromycin in Combination with Ceftriaxone Reduces Systemic Inflammation and Provides Survival Benefit in a Murine Model of Polymicrobial Sepsis Anasuya Patel, Jiji Joseph, Hariharan Periasamy, Santosh Mokale Antimicrobial Agents and Chemotherapy.2018;[Epub] CrossRef