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Korean J Crit Care Med > Volume 28(3); 2013 > Article
Korean Journal of Critical Care Medicine 2013;28(3): 234-238. doi: https://doi.org/10.4266/kjccm.2013.28.3.234
두개내압 감압을 위한 Propofol 혼수 치료를 받는 성인 환자에서 발생한 Propofol 정주 증후군
서울대학교병원 마취통증의학과
Propofol-Related Infusion Syndrome in an Adult Patient Using Propofol Coma Therapy to Control Intracranial Pressure
Sang Youn Park, Eu Gene Kim, Hee Pyoung Park
Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Korea. hppark@snu.ac.kr
Propofol-related infusion syndrome (PRIS) is a rare but fatal complication. Unexplained metabolic acidosis, rhabdomyolysis, hyperkalemia, myocardial dysfunction, cardiovascular collapse and acute kidney injury are the main characteristics of PRIS. Herein, we report a case of PRIS in a neurosurgical adult patient, who had received high-dose propofol continuous infusion in order to control intracranial pressure in an intensive care unit. She manifested severe metabolic acidosis, rhabdomyolysis, acute kidney injury and myocardial dysfunction. As soon as PRIS was diagnosed, propofol infusion was stopped. Conservative treatments, such as vasopressors and inotropics, continuous renal replacement therapy and extracorporeal membrane oxygenation were used to treat PRIS. However, she finally expired. This case report suggests that a great caution to PRIS is needed in a situation with high-dose propofol continuous infusion.
Key Words: intensive care unit; intracranial pressure; propofol-related infusion syndrome
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