Skip Navigation
Skip to contents

ACC : Acute and Critical Care

OPEN ACCESS
SEARCH
Search

Articles

Page Path
HOME > Acute Crit Care > Volume 27(1); 2012 > Article
Review Transfusion-related Acute Lung Injury
Miok Kim

DOI: https://doi.org/10.4266/kjccm.2012.27.1.1
Department of Internal Medicine, Jeju National Medical School, Jeju, Korea. miohkim@jejunu.ac.kr
  • 2,766 Views
  • 219 Download
  • 3 Crossref
  • 0 Scopus

Transfusion-related acute lung injury (TRALI) is a significant cause of iatrogenic injuries in patients. It is also the major cause of transfusion-associated fatalities. Pathophysiologic mechanism is an implicated donor of HLA. Neutrophil antibodies and biologic response modifiers are accumulated in the stored blood products. Pulmonary endothelial activation of the host may be the response from these mediators. Treatment is supportive and will be subjected to other forms of ALL/ARDS. Diverting donors at high risk for alloimmunization may decrease the incidence of such cases.


ACC : Acute and Critical Care