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Korean J Crit Care Med > Volume 26(3); 2011 > Article
Korean Journal of Critical Care Medicine 2011;26(3): 134-138. doi: https://doi.org/10.4266/kjccm.2011.26.3.134
CAPE가 내독소 유도에 의한 쥐 대식세포의 염증 반응 조절에 미치는 영향
이성헌ㆍ리매*ㆍ이대욱ㆍ임동윤ㆍ정철원ㆍ곽상현
Effect of Caffeic Acid Phenethyl Ester on Lipopolysaccharide-induced Murine Macrophage Activation
Seong Heon Lee, Mei Li, Dae Wook Lee, Dong Yun Lim, Cheol Won Jeong, Sang Hyun Kwak
1Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, Korea. shkwak@jnu.ac.kr
2Department of Anesthesiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
ABSTRACT
BACKGROUND: Caffeic acid phenethyl ester (CAPE) is an active component of propolis and is known to have anti-inflammatory properties. This study was performed to evaluate the effects of CAPE on lipopolysaccharide (LPS)-induced murine macrophage activation. METHODS: Raw 264.7 cells were incubated with varying concentrations of CAPE with or without LPS. The production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and macrophage inflammatory protein-2 (MIP-2) and activation of extracellular signal-regulated kinases 1/2 (ERK1/2), c-Jun amino terminal kinases (JNK) and p38 were measured. RESULTS: CAPE inhibited the production of TNF-alpha, IL-1beta and MIP-2 and attenuated phosphorylation levels of ERK1/2 and p38, but not JNK in RAW264.7 cells stimulated with LPS. CONCLUSIONS: CAPE can attenuate LPS-induced macrophage responses and we suggest that these effects may play an important role in modulating macrophage-mediated inflammatory responses in vivo.
Key Words: caffeic acid phenethyl ester; cytokines; mitogen-activated protein kinases
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