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Volume 35 (2); May 2020
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Review Article
Basic science and research
Sepsis-induced cardiac dysfunction: a review of pathophysiology
Reverien Habimana, Insu Choi, Hwa Jin Cho, Dowan Kim, Kyoseon Lee, Inseok Jeong
Acute Crit Care. 2020;35(2):57-66.   Published online May 31, 2020
DOI: https://doi.org/10.4266/acc.2020.00248
  • 17,612 View
  • 1,112 Download
  • 56 Web of Science
  • 57 Crossref
AbstractAbstract PDF
It is well known that cardiac dysfunction in sepsis is associated with significantly increased mortality. The pathophysiology of sepsis-induced cardiac dysfunction can be summarized as involving impaired myocardial circulation, direct myocardial depression, and mitochondrial dysfunction. Impaired blood flow to the myocardium is associated with microvascular dysfunction, impaired endothelium, and ventriculo-arterial uncoupling. The mechanisms behind direct myocardial depression consist of downregulation of β-adrenoceptors and several myocardial suppressants (such as cytokine and nitric oxide). Recent research has highlighted that mitochondrial dysfunction, which results in energy depletion, is a major factor in sepsis-induced cardiac dysfunction. Therefore, the authors summarize the pathophysiological process of cardiac dysfunction in sepsis based on the results of recent studies.

Citations

Citations to this article as recorded by  
  • Neonatal sepsis and cardiovascular dysfunction I: mechanisms and pathophysiology
    Sophie M. Duignan, Satyan Lakshminrusimha, Kathryn Armstrong, Willem P. de Boode, Afif El-Khuffash, Orla Franklin, Eleanor J. Molloy, Willem P. de Boode, Franz B. Plötz, Tobias Strunk, Marina Degtyareva, Helmut Küster, Eric Giannoni, Joseph M. Bliss, H. R
    Pediatric Research.2024; 95(5): 1207.     CrossRef
  • 6-Gingerol, an ingredient of Zingiber officinale, abrogates lipopolysaccharide-induced cardiomyocyte injury by reducing oxidative stress and inflammation
    Azar Hosseini, Mohaddeseh Sadat Alavi, Mitra Ghane Nikookar Toos, Tannaz Jamialahmadi, Amirhossein Sahebkar
    Journal of Agriculture and Food Research.2024; 15: 101034.     CrossRef
  • Inflammation and arrhythmogenesis: a narrative review of the complex relationship
    Andia Taghdiri
    International Journal of Arrhythmia.2024;[Epub]     CrossRef
  • Inotropic drugs in septic shock
    Nutnicha Yolsiriwat, Surat Tongyoo
    Clinical Critical Care.2024;[Epub]     CrossRef
  • Epigallocatechin-3-gallate protects sepsis‐induced myocardial dysfunction by inhibiting the nuclear factor-κB signaling pathway
    Bei Chen, Ya-Fei Li, Zhang Fang, Wen-Yi Cai, Zhi-Qiang Tian, Dianfu Li, Ze-Mu Wang
    Heliyon.2024; 10(5): e27163.     CrossRef
  • Myocardial Injury as a Harbinger of Multi-organ Failure in Septic Shock: A Comprehensive Review
    Amol Singam
    Cureus.2024;[Epub]     CrossRef
  • Case 9-2024: An 84-Year-Old Man with a Fall
    Richard C. Cabot, Eric S. Rosenberg, David M. Dudzinski, Meridale V. Baggett, Kathy M. Tran, Dennis C. Sgroi, Jo-Anne O. Shepard, Emily K. McDonald, Tara Corpuz, Zaven Sargsyan, Sunita D. Srivastava, Virginia A. Triant, Brian B. Ghoshhajra
    New England Journal of Medicine.2024; 390(12): 1129.     CrossRef
  • Melatonin: A potential protective multifaceted force for sepsis-induced cardiomyopathy
    Eman Casper, Lamia El Wakeel, Nagwa Sabri, Ramy Khorshid, Sarah F. Fahmy
    Life Sciences.2024; 346: 122611.     CrossRef
  • Hemodynamic goals in sepsis and septic shock resuscitation: An umbrella review of systematic reviews and meta-analyses with trial sequential analysis
    Daniele Orso, Nicola Federici, Cristina Lio, Filippo Mearelli, Tiziana Bove
    Australian Critical Care.2024; 37(5): 818.     CrossRef
  • NOVEL ECHOCARDIOGRAM ANALYSIS OF CARDIAC DYSFUNCTION IS ASSOCIATED WITH MORTALITY IN PEDIATRIC SEPSIS
    Daniel T. Cater, Brett A. Meyers, Shailee Mitra, Sayantan Bhattacharya, Roberto F. Machado, Ryan Serrano, Courtney M. Rowan, Benjamin Gaston, Pavlos Vlachos
    Shock.2024; 62(1): 26.     CrossRef
  • From Molecular Mechanisms to Clinical Therapy: Understanding Sepsis-Induced Multiple Organ Dysfunction
    Tijana Srdić, Siniša Đurašević, Iva Lakić, Aleksandra Ružičić, Predrag Vujović, Tanja Jevđović, Tamara Dakić, Jelena Đorđević, Tomislav Tosti, Sofija Glumac, Zoran Todorović, Nebojša Jasnić
    International Journal of Molecular Sciences.2024; 25(14): 7770.     CrossRef
  • Endothelial α1-adrenergic receptor activation improves cardiac function in septic mice via PKC-ERK/p38MAPK signaling pathway
    Tian Tian, Qing Yu, Duomeng Yang, Xue Zhang, Chanjuan Zhang, Jianling Li, Tao Luo, Keke Zhang, Xiuxiu Lv, Yiyang Wang, Huadong Wang, Hongmei Li
    International Immunopharmacology.2024; 141: 112937.     CrossRef
  • Cecal necroptosis triggers lethal cardiac dysfunction in TNF-induced severe SIRS
    Jianfeng Wu, Tingting Ai, Peng He, Qilin Shi, Yangxin Li, Ziguan Zhang, Minwei Chen, Zhengrong Huang, Suqin Wu, Wanze Chen, Jiahuai Han
    Cell Reports.2024; 43(10): 114778.     CrossRef
  • m6A methylation in myocardial tissue of septic mice analyzed using MeRIP/m6A-sequencing and RNA-sequencing
    Xue Liang, Xiaotong Hu, Jiao Li, Boyang Zhang, Tianshu Gu, Hualing Wang, Mingzhong Zhang, Xiaodong Xia, Siyu Guan, Wenfeng Shangguan, Shuai Miao, Weiding Wang, Hao Zhang, Zhiqiang Zhao, Lijun Wang
    Functional & Integrative Genomics.2024;[Epub]     CrossRef
  • MMP-8 causes leftward shift in end-diastolic pressure-volume relationship and may explain the development of diastolic dysfunction in septic cardiomyopathy
    Ida Maiorov, Konstantin Bagrov, Roy Efraim, Galit Ankri Eliyahu, Amit Livneh, Amir Landesberg
    American Journal of Physiology-Heart and Circulatory Physiology.2024; 327(4): H1098.     CrossRef
  • Possible mechanisms of SARS-CoV-2-associated myocardial fibrosis: reflections in the post-pandemic era
    Zhan Wang, Luwei Li, Shuai Yang, Zhengrui Li, Pengpeng Zhang, Run Shi, Xing Zhou, Xiaojuan Tang, Qi Li
    Frontiers in Microbiology.2024;[Epub]     CrossRef
  • The association between integrating echocardiography use in the management of septic shock patients and outcomes in the intensive care unit: a systematic review and meta-analysis
    Keith Killu, Cecilia Patino-Sutton, Lynn Kysh, Richard Castriotta, John Oropello, Luis Huerta, Dominic Engracia, Karim Merchant, Choo Phei Wee, Victoria Kristence Cortessis
    Journal of Ultrasound.2024;[Epub]     CrossRef
  • Septic Cardiomyopathy
    Ivana Lukić, Damir Mihić, Silvija Canecki Varžić, Kristina Selthofer Relatić, Lada Zibar, Domagoj Loinjak, Željka Breškić Ćurić, Lucija Klobučar, Lana Maričić
    Reviews in Cardiovascular Medicine.2024;[Epub]     CrossRef
  • A case of sepsis‐induced cardiomyopathy successfully treated with venoarterial extracorporeal membrane oxygenation
    Keigo Sato, Akihiro Naito, Taichi Shiratori, Masahiro Yamamoto, Kenichi Shimane, Manabu Mikami, Mariko Senda, Haruki Kume, Motofumi Suzuki
    IJU Case Reports.2023; 6(1): 26.     CrossRef
  • Jujuboside A attenuates sepsis-induced cardiomyopathy by inhibiting inflammation and regulating autophagy
    Zi Wang, Danrui Xiao, Qingqi Ji, Yanjie Li, Zhaohua Cai, Liang Fang, Huanhuan Huo, Guo Zhou, Xiangming Yan, Linghong Shen, Ben He
    European Journal of Pharmacology.2023; 947: 175451.     CrossRef
  • Mitochondrial transplantation protects against sepsis-induced myocardial dysfunction by modulating mitochondrial biogenesis and fission/fusion and inflammatory response
    Behnaz Mokhtari, Masoud Hamidi, Reza Badalzadeh, Ata Mahmoodpoor
    Molecular Biology Reports.2023; 50(3): 2147.     CrossRef
  • Therapeutic potentials of stem cell–derived exosomes in cardiovascular diseases
    Saiprahalad Mani, Narasimman Gurusamy, Thennavan Ulaganathan, Autumn J Paluck, Satish Ramalingam, Johnson Rajasingh
    Experimental Biology and Medicine.2023; 248(5): 434.     CrossRef
  • CLINICAL, MOLECULAR, AND EXOSOMAL MECHANISMS OF CARDIAC AND BRAIN DYSFUNCTION IN SEPSIS
    Daniel C. Morris, Zheng Gang Zhang, Anja K. Jaehne, Jing Zhang, Emanuel P. Rivers
    Shock.2023; 59(2): 173.     CrossRef
  • Circulating protein and lipid markers of early sepsis diagnosis and prognosis: a scoping review
    Gemma Barber, Jelena Tanic, Aleksandra Leligdowicz
    Current Opinion in Lipidology.2023; 34(2): 70.     CrossRef
  • Extracellular Histone-Induced Protein Kinase C Alpha Activation and Troponin Phosphorylation Is a Potential Mechanism of Cardiac Contractility Depression in Sepsis
    Simon T. Abrams, Yasir Alhamdi, Min Zi, Fengmei Guo, Min Du, Guozheng Wang, Elizabeth J. Cartwright, Cheng-Hock Toh
    International Journal of Molecular Sciences.2023; 24(4): 3225.     CrossRef
  • Septic cardiomyopathy: A narrative review
    Maria Rita Lima, Doroteia Silva
    Revista Portuguesa de Cardiologia.2023; 42(5): 471.     CrossRef
  • Enfoque de la miocardiopatía séptica como causa de choque refractario en escenarios de recursos limitados: reporte de caso
    Liliana Correa-Pérez, Diana Carolina Otálora Álvarez, Gloria Camila Álvarez Gallego
    Acta Colombiana de Cuidado Intensivo.2023; 23(3): 303.     CrossRef
  • Role of Pellino-1 in Inflammation and Cardioprotection following Severe Sepsis: A Novel Mechanism in a Murine Severe Sepsis Model †
    Mahesh Thirunavukkarasu, Santosh Swaminathan, Andrew Kemerley, Seetur R. Pradeep, Sue Ting Lim, Diego Accorsi, Rickesha Wilson, Jacob Campbell, Ibnalwalid Saad, Siu-Pok Yee, J. Alexander Palesty, David W. McFadden, Nilanjana Maulik
    Cells.2023; 12(11): 1527.     CrossRef
  • circHIPK3 exacerbates sepsis-induced acute kidney injury and cardiopulmonary function by regulating microRNA-106a-5p/ROCK2 axis
    Heng Li, Lingkai Kang, Jianglu Tan, Wanli Li, Dongrui He, Jing Han, Jie Zhang, Yulin Guan, Ying Huang, Xiaoyue Li
    Process Biochemistry.2023; 131: 272.     CrossRef
  • Estradiol as the Trigger of Sirtuin-1-Dependent Cell Signaling with a Potential Utility in Anti-Aging Therapies
    Kamil Karolczak, Cezary Watala
    International Journal of Molecular Sciences.2023; 24(18): 13753.     CrossRef
  • RETRACTED: Baricitinib protects mice from sepsis-induced cardiac dysfunction and multiple-organ failure
    Chiara Verra, Shireen Mohammad, Gustavo Ferreira Alves, Elisa Porchietto, Sina Maren Coldewey, Massimo Collino, Christoph Thiemermann
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction
    Gabriel Jakobsson, Praveen Papareddy, Henrik Andersson, Megan Mulholland, Ravi Bhongir, Irena Ljungcrantz, Daniel Engelbertsen, Harry Björkbacka, Jan Nilsson, Adrian Manea, Heiko Herwald, Marisol Ruiz-Meana, Antonio Rodríguez-Sinovas, Michelle Chew, Alexa
    Critical Care.2023;[Epub]     CrossRef
  • Cardiac troponin as a prognosticator of mortality in patients with sepsis: A systematic review and meta‐analysis
    Peiqiu Zheng, Xing Wang, Tao Guo, Wei Gao, Qiang Huang, Jie Yang, Hui Gao, Qian Liu
    Immunity, Inflammation and Disease.2023;[Epub]     CrossRef
  • Decoding molecular signature on heart of septic mice with distinct left ventricular ejection fraction
    Lina Zhang, Desheng Qi, Milin Peng, Binbin Meng, Xinrun Wang, Xiaolei Zhang, Zhihong Zuo, Li Li, Zhanwen Wang, Wenxuan Zou, Zhonghua Hu, Zhaoxin Qian
    iScience.2023; 26(10): 107825.     CrossRef
  • Role of toll-like receptor-mediated pyroptosis in sepsis-induced cardiomyopathy
    Yixuan Fan, Baoyi Guan, Jianxing Xu, He Zhang, Liang Yi, Zhixu Yang
    Biomedicine & Pharmacotherapy.2023; 167: 115493.     CrossRef
  • Understanding yellow fever-associated myocardial injury: an autopsy study
    Fernando Rabioglio Giugni, Vera Demarchi Aiello, Caroline Silverio Faria, Shahab Zaki Pour, Marielton dos Passos Cunha, Melina Valdo Giugni, Henrique Trombini Pinesi, Felipe Lourenço Ledesma, Carolina Esteves Morais, Yeh-Li Ho, Jaques Sztajnbok, Sandra de
    eBioMedicine.2023; 96: 104810.     CrossRef
  • The role of beta-blocker drugs in critically ill patients: a SIAARTI expert consensus statement
    Fabio Guarracino, Andrea Cortegiani, Massimo Antonelli, Astrid Behr, Giandomenico Biancofiore, Alfredo Del Gaudio, Francesco Forfori, Nicola Galdieri, Giacomo Grasselli, Gianluca Paternoster, Monica Rocco, Stefano Romagnoli, Salvatore Sardo, Sascha Treska
    Journal of Anesthesia, Analgesia and Critical Care.2023;[Epub]     CrossRef
  • Sedation for Patients with Sepsis: Towards a Personalised Approach
    José Miguel Marcos-Vidal, Rafael González, María Merino, Eva Higuera, Cristina García
    Journal of Personalized Medicine.2023; 13(12): 1641.     CrossRef
  • High serum nitrates levels in non-survivor COVID-19 patients
    L. Lorente, F. Gómez-Bernal, M.M. Martín, J.A. Navarro-Gonzálvez, M. Argueso, A. Perez, L. Ramos-Gómez, J. Solé-Violán, J.A. Marcos y Ramos, N. Ojeda, A. Jiménez
    Medicina Intensiva.2022; 46(3): 132.     CrossRef
  • Vital signs as physiomarkers of neonatal sepsis
    Brynne A. Sullivan, Karen D. Fairchild
    Pediatric Research.2022; 91(2): 273.     CrossRef
  • Fluid therapy for severe malaria
    Laura C Kalkman, Thomas Hänscheid, Sanjeev Krishna, Martin P Grobusch
    The Lancet Infectious Diseases.2022; 22(6): e160.     CrossRef
  • High serum nitrates levels in non-survivor COVID-19 patients
    L. Lorente, F. Gómez-Bernal, M.M. Martín, J.A. Navarro-Gonzálvez, M. Argueso, A. Perez, L. Ramos-Gómez, J. Solé-Violán, J.A. Marcos y Ramos, N. Ojeda, A. Jiménez
    Medicina Intensiva (English Edition).2022; 46(3): 132.     CrossRef
  • Expression of Peripheral Blood DCs CD86, CD80, and Th1/Th2 in Sepsis Patients and Their Value on Survival Prediction
    Ke Du, Shaobo Hao, Heyun Luan, Min Tang
    Computational and Mathematical Methods in Medicine.2022; 2022: 1.     CrossRef
  • Recombinant Activated Protein C (rhAPC) Affects Lipopolysaccharide-Induced Mechanical Compliance Changes and Beat Frequency of mESC-Derived Cardiomyocyte Monolayers
    Aysegül Temiz Artmann, Eylem Kurulgan Demirci, Ipek Seda Fırat, Hakan Oflaz, Gerhard M. Artmann
    Shock.2022; 57(4): 544.     CrossRef
  • Acute cholecystitis associated with sepsis-induced ischemic cardiomyopathy
    Ke-Shiuan Ju, Ying-Shih Su, Wen-Sen Lee
    Journal of Infection.2022; 84(6): 834.     CrossRef
  • An Overview on Mitochondrial-Based Therapies in Sepsis-Related Myocardial Dysfunction: Mitochondrial Transplantation as a Promising Approach
    Behnaz Mokhtari, Rana Yavari, Reza Badalzadeh, Ata Mahmoodpoor, Jayaraman Tharmalingam
    Canadian Journal of Infectious Diseases and Medical Microbiology.2022; 2022: 1.     CrossRef
  • Pathological role of the calcium‐sensing receptor in sepsis‐induced hypotensive shock: Therapeutic possibilities and unanswered questions
    Ankita Sood, Gaaminepreet Singh, Thakur G. Singh, Kirti Gupta
    Drug Development Research.2022; 83(6): 1241.     CrossRef
  • Diminazene aceturate mitigates cardiomyopathy by interfering with renin-angiotensin system in a septic rat model
    Zhaoqing Lu, Di Wu, Zheng Wang, Hanyu Zhang, Yufan Du, Guoxing Wang
    BMC Pharmacology and Toxicology.2022;[Epub]     CrossRef
  • Serum Sestrin2 Was Lower in Septic Shock Patients with Cardiomyopathy
    Rongjin Huang, Feng Chen, Aiying Zeng, Jun Ke, Shirong Lin, QiXing Chen
    Disease Markers.2022; 2022: 1.     CrossRef
  • Tidy up - The unfolded protein response in sepsis
    Wolfgang Vivas, Sebastian Weis
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • DAMPs Released from Proinflammatory Macrophages Induce Inflammation in Cardiomyocytes via Activation of TLR4 and TNFR
    Carolina Neu, Yvonne Thiele, Fabienne Horr, Christian Beckers, Nadine Frank, Gernot Marx, Lukas Martin, Sandra Kraemer, Elisabeth Zechendorf
    International Journal of Molecular Sciences.2022; 23(24): 15522.     CrossRef
  • Targeting the TXNIP‐NLRP3 interaction with PSSM1443 to suppress inflammation in sepsis‐induced myocardial dysfunction
    Linhua Wang, Hongsheng Zhao, Huifen Xu, Xiangxin Liu, Xinlong Chen, Qingyun Peng, Mingbing Xiao
    Journal of Cellular Physiology.2021; 236(6): 4625.     CrossRef
  • Sepsis—Pathophysiology and Therapeutic Concepts
    Dominik Jarczak, Stefan Kluge, Axel Nierhaus
    Frontiers in Medicine.2021;[Epub]     CrossRef
  • Rho-Proteins and Downstream Pathways as Potential Targets in Sepsis and Septic Shock: What Have We Learned from Basic Research
    Maria Luísa da Silveira Hahmeyer, José Eduardo da Silva-Santos
    Cells.2021; 10(8): 1844.     CrossRef
  • Deep-learning model for screening sepsis using electrocardiography
    Joon-myoung Kwon, Ye Rang Lee, Min-Seung Jung, Yoon-Ji Lee, Yong-Yeon Jo, Da-Young Kang, Soo Youn Lee, Yong-Hyeon Cho, Jae-Hyun Shin, Jang-Hyeon Ban, Kyung-Hee Kim
    Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine.2021;[Epub]     CrossRef
  • Levosimendan versus dobutamine for sepsis-induced cardiac dysfunction: a systematic review and meta-analysis
    Dong-Hua Liu, Yi-Le Ning, Yan-Yan Lei, Jing Chen, Yan-Yan Liu, Xin-Feng Lin, Zhong-Qi Yang, Shao-Xiang Xian, Wei-Tao Chen
    Scientific Reports.2021;[Epub]     CrossRef
  • Exosomes Derived from miR-146a-5p-Enriched Mesenchymal Stem Cells Protect the Cardiomyocytes and Myocardial Tissues in the Polymicrobial Sepsis through Regulating MYBL1
    Chun Liu, Jianhua Xue, Bo Xu, Aixian Zhang, Lili Qin, Jiajia Liu, Yang Yang, Antonio C. Campos de Carvalho
    Stem Cells International.2021; 2021: 1.     CrossRef
Original Articles
Cardiology
Predictors and outcomes of sepsis-induced cardiomyopathy in critically ill patients
Myung Jin Song, Sang Hoon Lee, Ah Young Leem, Song Yee Kim, Kyung Soo Chung, Eun Young Kim, Ji Ye Jung, Young Ae Kang, Young Sam Kim, Joon Chang, Moo Suk Park
Acute Crit Care. 2020;35(2):67-76.   Published online May 15, 2020
DOI: https://doi.org/10.4266/acc.2020.00024
  • 7,605 View
  • 233 Download
  • 10 Web of Science
  • 11 Crossref
AbstractAbstract PDF
Background
Sepsis-induced cardiomyopathy (SIC) occurs frequently in critically ill patients, but the clinical features and prognostic impact of SIC on sepsis outcome remain controversial. Here, we investigated the predictors and outcomes of SIC.
Methods
Patients admitted to a single medical intensive care unit from June 2016 to September 2017 were retrospectively reviewed. SIC was diagnosed by ejection fraction (EF) <50% and ≥10% decrease in baseline EF that recovered within 2 weeks.
Results
In total, 342 patients with sepsis met the inclusion criteria, and 49 patients (14.3%) were diagnosed with SIC; the latter were compared with 259 patients whose EF was not deteriorated by sepsis (non-SIC). Low systolic blood pressure and increased left ventricular end-diastolic diameter (LVEDD) were identified as predictors of SIC. SIC and non-SIC patients did not differ significantly in terms of 28-day all-cause mortality (24.5% vs. 26.3%, P=0.936). Acute Physiology and Chronic Health Evaluation II (APACHE II; hazard ratio [HR], 1.10; 95% confidential interval [CI], 1.02 to 1.18; P=0.009) and delta neutrophil index (DNI; HR, 1.02; 95% CI, 1.00 to 1.08; P=0.026) were independent risk factors for 28-day mortality with SIC. DNI, APACHE II, and lactate were identified as risk factors for 28-day mortality in sepsis patients as a whole.
Conclusions
SIC was not associated with increased mortality compared to non-SIC. Low systolic blood pressure and increased LVEDD were predictors of SIC. High APACHE II score and elevated DNI, which reflect sepsis severity, predict 28-day all-cause mortality.

Citations

Citations to this article as recorded by  
  • Testosterone and soluble ST2 as mortality predictive biomarkers in male patients with sepsis-induced cardiomyopathy
    Lu Wang, Wen Dai, Ruiyao Zhu, Tingting Long, Zhaocai Zhang, Zhenju Song, Sucheng Mu, Shasha Wang, Huijuan Wang, Jiaxi Lei, Jing Zhang, Wenfang Xia, Guang Li, Wenwei Gao, Handong Zou, Yan Li, Liying Zhan
    Frontiers in Medicine.2024;[Epub]     CrossRef
  • Meta-Analysis of Initial Natriuretic Peptides in the Setting of Sepsis-Induced Myocardial Dysfunction
    Boyong He, Xin Wang, Liguo Shi, Hongbin Cheng, Luyi Zhao
    Biomarkers in Medicine.2024; 18(4): 145.     CrossRef
  • Prevalence and Prognosis of Sepsis-Induced Cardiomyopathy: A Systematic Review and Meta-Analysis
    Daisuke Hasegawa, Yoshiko Ishisaka, Tetsuro Maeda, Narut Prasitlumkum, Kazuki Nishida, Siddharth Dugar, Ryota Sato
    Journal of Intensive Care Medicine.2023; 38(9): 797.     CrossRef
  • Research Progress on the Mechanism and Management of Septic Cardiomyopathy: A Comprehensive Review
    Xue-Bin Pei, Bo Liu, Maciej Dyrbuś
    Emergency Medicine International.2023; 2023: 1.     CrossRef
  • Biomarkers to Predict Multiorgan Distress Syndrome and Acute Kidney Injury in Critically Ill Surgical Patients
    In Sik Shin, Da Kyung Kim, Sanghyun An, Sung Chan Gong, Moo Hyun Kim, Md Habibur Rahman, Cheol-Su Kim, Joon Hyeong Sohn, Kwangmin Kim, Hoon Ryu
    Medicina.2023; 59(12): 2054.     CrossRef
  • Risk factors of postoperative septic cardiomyopathy in perioperative sepsis patients
    Yuchang Xin, Ying Ge, Liuhui Chang, Yong Ni, Hairui Liu, Jiang Zhu
    BMC Anesthesiology.2022;[Epub]     CrossRef
  • Effect of milrinone versus placebo on hemodynamic in patients with septic shock: A randomize control trial
    Suratee Chobngam, Surat Tongyoo
    Clinical Critical Care.2022;[Epub]     CrossRef
  • Association of sepsis-induced cardiomyopathy and mortality: a systematic review and meta-analysis
    Yu-Min Lin, Mei-Chuan Lee, Han Siong Toh, Wei-Ting Chang, Sih-Yao Chen, Fang-Hsiu Kuo, Hsin-Ju Tang, Yi-Ming Hua, Dongmei Wei, Jesus Melgarejo, Zhen-Yu Zhang, Chia-Te Liao
    Annals of Intensive Care.2022;[Epub]     CrossRef
  • Association of Sepsis-Induced Cardiomyopathy and Mortality: A Systematic Review and Meta-Analysis
    Yu-Min Lin, Mei-Chuan Lee, Han Siong Toh, Wei-Ting Chang, Sih-Yao Chen, Fang-Hsiu Kuo, Hsin-Ju Tang, Yi-Ming Hua, Dongmei Wei, Jesus Melgarejo, Zhen-Yu Zhang, Chia-Te Liao
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • Sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsis
    Balaram Krishna J Hanumanthu, Anika Sasidharan Nair, Adarsh Katamreddy, Jason S Gilbert, Jee Young You, Obiageli Lynda Offor, Ankit Kushwaha, Ankita Krishnan, Marzio Napolitano, Leonidas Palaidimos, Joaquin Morante, Seema S. Tekwani, Suchita Mehta, Aancha
    Acute and Critical Care.2021; 36(3): 215.     CrossRef
  • The Correlation Between Whole Blood Copper (Cu), Zinc (Zn) Levels and Cu/Zn Ratio and Sepsis-Induced Left Ventricular Systolic Dysfunction (SILVSD) in Patients with Septic Shock: A Single-Center Prospective Observational Study
    Jian-Biao Meng, Ma-Hong Hu, Ming Zhang, Gong-Pai Hu, Wei Zhang, Shen-Jiang Hu
    International Journal of General Medicine.2021; Volume 14: 7219.     CrossRef
Rapid response system
Effectiveness of a daytime rapid response system in hospitalized surgical ward patients
Eunjin Yang, Hannah Lee, Sang-Min Lee, Sulhee Kim, Ho Geol Ryu, Hyun Joo Lee, Jinwoo Lee, Seung-Young Oh
Acute Crit Care. 2020;35(2):77-86.   Published online May 13, 2020
DOI: https://doi.org/10.4266/acc.2019.00661
  • 7,270 View
  • 226 Download
  • 7 Web of Science
  • 9 Crossref
AbstractAbstract PDFSupplementary Material
Background
Clinical deteriorations during hospitalization are often preventable with a rapid response system (RRS). We aimed to investigate the effectiveness of a daytime RRS for surgical hospitalized patients.
Methods
A retrospective cohort study was conducted in 20 general surgical wards at a 1,779-bed University hospital from August 2013 to July 2017 (August 2013 to July 2015, pre-RRS-period; August 2015 to July 2017, post-RRS-period). The primary outcome was incidence of cardiopulmonary arrest (CPA) when the RRS was operating. The secondary outcomes were the incidence of total and preventable cardiopulmonary arrest, in-hospital mortality, the percentage of “do not resuscitate” orders, and the survival of discharged CPA patients.
Results
The relative risk (RR) of CPA per 1,000 admissions during RRS operational hours (weekdays from 7 AM to 7 PM) in the post-RRS-period compared to the pre-RRS-period was 0.53 (95% confidence interval [CI], 0.25 to 1.13; P=0.099) and the RR of total CPA regardless of RRS operating hours was 0.76 (95% CI, 0.46 to 1.28; P=0.301). The preventable CPA after RRS implementation was significantly lower than that before RRS implementation (RR, 0.31; 95% CI, 0.11 to 0.88; P=0.028). There were no statistical differences in in-hospital mortality and the survival rate of patients with in-hospital cardiac arrest. Do-not-resuscitate decisions significantly increased during after RRS implementation periods compared to pre-RRS periods (RR, 1.91; 95% CI, 1.40 to 2.59; P<0.001).
Conclusions
The day-time implementation of the RRS did not significantly reduce the rate of CPA whereas the system effectively reduced the rate of preventable CPA during periods when the system was operating.

Citations

Citations to this article as recorded by  
  • Development and Validation of a Machine Learning Algorithm Using Clinical Pages to Predict Imminent Clinical Deterioration
    Bryan D. Steitz, Allison B. McCoy, Thomas J. Reese, Siru Liu, Liza Weavind, Kipp Shipley, Elise Russo, Adam Wright
    Journal of General Internal Medicine.2024; 39(1): 27.     CrossRef
  • Effects of a Rapid Response Team on Patient Outcomes: A Systematic Review
    Qiuxia Zhang, Khuan Lee, Zawiah Mansor, Iskasymar Ismail, Yi Guo, Qiao Xiao, Poh Ying Lim
    Heart & Lung.2024; 63: 51.     CrossRef
  • Development and Validation of a Deep Learning Model for Prediction of Adult Physiological Deterioration
    Supreeth P. Shashikumar, Joshua Pei Le, Nathan Yung, James Ford, Karandeep Singh, Atul Malhotra, Shamim Nemati, Gabriel Wardi
    Critical Care Explorations.2024; 6(9): e1151.     CrossRef
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    Kyoung Won Yoon, Kyoungjin Choi, Keesang Yoo, Eunmi Gil, Chi-Min Park
    Annals of Surgical Treatment and Research.2023; 104(1): 43.     CrossRef
  • The associations between rapid response systems and their components with patient outcomes: A scoping review
    Rebecca J. Piasecki, Cheryl R. Dennison Himmelfarb, Kelly T. Gleason, Rachel M. Justice, Elizabeth A. Hunt
    International Journal of Nursing Studies Advances.2023; 5: 100134.     CrossRef
  • Changes in the incidence of cardiopulmonary resuscitation before and after implementation of the Life-Sustaining Treatment Decisions Act
    Hyunjae Im, Hyun Woo Choe, Seung-Young Oh, Ho Geol Ryu, Hannah Lee
    Acute and Critical Care.2022; 37(2): 237.     CrossRef
  • Estructura y función de los equipos de respuesta rápida para la atención de adultos en contextos hospitalarios de alta complejidad: Revisión sistemática de alcance
    Juliana Vanessa Rincón-López, Diego Larrotta-Castillo, Kelly Estrada-Orozco, Hernando Gaitán-Duarte
    Revista Colombiana de Obstetricia y Ginecología.2021; 72(2): 171.     CrossRef
  • Characteristics and Prognosis of Hospitalized Patients at High Risk of Deterioration Identified by the Rapid Response System: a Multicenter Cohort Study
    Sang Hyuk Kim, Ji Young Hong, Youlim Kim
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Effects of a Rapid Response Team on the Clinical Outcomes of Cardiopulmonary Resuscitation of Patients Hospitalized in General Wards
    Mi-Jung Yoon, Jin-Hee Park
    Journal of Korean Academy of Fundamentals of Nursing.2021; 28(4): 491.     CrossRef
Pediatric
Effects of the presence of a pediatric intensivist on treatment in the pediatric intensive care unit
Jung Eun Kwon, Da Eun Roh, Yeo Hyang Kim
Acute Crit Care. 2020;35(2):87-92.   Published online May 12, 2020
DOI: https://doi.org/10.4266/acc.2019.00752
  • 4,916 View
  • 101 Download
  • 3 Web of Science
  • 3 Crossref
AbstractAbstract PDF
Background
There are few studies on the effect of intensivist staffing in pediatric intensive care units (PICUs) in Korea. We aimed to evaluate the effect of pediatric intensivist staffing on treatment outcomes in a Korean hospital PICU.
Methods
We analyzed two time periods according to pediatric intensivist staffing: period 1, between November 2015 to January 2017 (no intensivist staffing, n=97) and period 2, between February 2017 to February 2018 (intensivists staffing, n=135).
Results
Median age at admission was 5.4 years (range, 0.7–10.3 years) in period 1 and 3.6 years (0.2–5.1 years) in period 2 (P=0.013). The bed occupancy rate decreased in period 2 (75%; 73%–88%) compared to period 1 (89%; 81%–94%; P=0.015). However, the monthly bed turnover rate increased in period 2 (2.2%; 1.9%–2.7%) compared to period 1 (1.5%, 1.1%– 1.7%; P=0.005). In both periods, patients with chronic neurologic illness were the most common. Patients with cardiovascular problems were more prevalent in period 2 than period 1 (P=0.008). Daytime admission occurred more frequently in period 2 than period 1 (63% vs. 39%, P<0.001). The length of PICU stay, parameters related with mechanical ventilation and tracheostomy, and pediatric Sequential Organ Failure Assessment score were not different between periods. Sudden cardiopulmonary resuscitations occurred in two cases during period 1, but no case occurred during period 2.
Conclusions
Pediatric intensivist staffing in the PICU may affect efficient ICU operations.

Citations

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  • The impact of pediatric intensivists on the management of pediatric diabetic ketoacidosis in pediatric intensive care units
    Ah Young Choi, Esther Park
    BMC Pediatrics.2023;[Epub]     CrossRef
  • Impact of staffing model conversion from a mandatory critical care consultation model to a closed unit model in the medical intensive care unit
    Sung Jun Ko, Jaeyoung Cho, Sun Mi Choi, Young Sik Park, Chang-Hoon Lee, Chul-Gyu Yoo, Jinwoo Lee, Sang-Min Lee, Robert Jeenchen Chen
    PLOS ONE.2021; 16(10): e0259092.     CrossRef
  • Intensivists in the pediatric intensive care unit: conductors for better operational efficiency
    June Dong Park
    Acute and Critical Care.2020; 35(2): 115.     CrossRef
CPR/Resuscitation
Measurement of mean systemic filling pressure after severe hemorrhagic shock in swine anesthetized with propofol-based total intravenous anesthesia: implications for vasopressor-free resuscitation
Athanasios Chalkias, Anastasios Koutsovasilis, Eleni Laou, Apostolos Papalois, Theodoros Xanthos
Acute Crit Care. 2020;35(2):93-101.   Published online April 20, 2020
DOI: https://doi.org/10.4266/acc.2019.00773
  • 7,273 View
  • 158 Download
  • 8 Web of Science
  • 8 Crossref
AbstractAbstract PDF
Background
Mean systemic filling pressure (Pmsf) is a quantitative measurement of a patient’s volume status and represents the tone of the venous reservoir. The aim of this study was to estimate Pmsf after severe hemorrhagic shock and cardiac arrest in swine anesthetized with propofol-based total intravenous anesthesia, as well as to evaluate Pmsf’s association with vasopressor-free resuscitation.
Methods
Ten healthy Landrace/Large-White piglets aged 10–12 weeks with average weight 20±1 kg were used in this study. The protocol was divided into four distinct phases: stabilization, hemorrhagic, cardiac arrest, and resuscitation phases. We measured Pmsf at 5–7.5 seconds after the onset of cardiac arrest and then every 10 seconds until 1 minute postcardiac arrest. During resuscitation, lactated Ringers was infused at a rate that aimed for a mean right atrial pressure of ≤4 mm Hg. No vasopressors were used.
Results
The mean volume of blood removed was 860±20 ml (blood loss, ~61%) and the bleeding time was 43.2±2 minutes while all animals developed pulseless electrical activity. Mean Pmsf was 4.09±1.22 mm Hg, and no significant differences in Pmsf were found until 1 minute postcardiac arrest (4.20±0.22 mm Hg at 5–7.5 seconds and 3.72±0.23 mm Hg at 55– 57.5 seconds; P=0.102). All animals achieved return of spontaneous circulation (ROSC), with mean time to ROSC being 6.1±1.7 minutes and mean administered volume being 394±20 ml.
Conclusions
For the first time, Pmsf was estimated after severe hemorrhagic shock. In this study, Pmsf remained stable during the first minute post-arrest. All animals achieved ROSC with goal-directed fluid resuscitation and no vasopressors.

Citations

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  • COMPARISON BETWEEN ACTIVE ABDOMINAL COMPRESSION-DECOMPRESSION CARDIOPULMONARY RESUSCITATION AND STANDARD CARDIOPULMONARY RESUSCITATION IN ASPHYCTIC CARDIAC ARREST RATS WITH MULTIPLE RIB FRACTURES
    Zhichu Dai, Sisen Zhang, Hongyu Wang, Liwei He, Jiankun Liao, Xuanyu Wu
    Shock.2024; 61(2): 266.     CrossRef
  • Effects of Vasopressin Receptor Agonists during the Resuscitation of Hemorrhagic Shock: A Systematic Review and Meta-Analysis of Experimental and Clinical Studies
    Eleni Laou, Nikolaos Papagiannakis, Androniki Papadopoulou, Theodora Choratta, Minas Sakellakis, Mariachiara Ippolito, Ioannis Pantazopoulos, Andrea Cortegiani, Athanasios Chalkias
    Journal of Personalized Medicine.2023; 13(7): 1143.     CrossRef
  • Hemodynamic Effects of Cardiovascular Medications in a Normovolemic and Hemorrhaged Yorkshire-cross Swine Model
    Jacob H Cole, Scott B Hughey, Phillip G Geiger, Kamala J Rapp-Santos, Gregory J Booth
    Comparative Medicine.2022; 72(1): 38.     CrossRef
  • Determinants of venous return in steady-state physiology and asphyxia-induced circulatory shock and arrest: an experimental study
    Athanasios Chalkias, Eleni Laou, Nikolaos Papagiannakis, Giolanda Varvarousi, Dimitrios Ragias, Anastasios Koutsovasilis, Demosthenes Makris, Dimitrios Varvarousis, Nicoletta Iacovidou, Ioannis Pantazopoulos, Theodoros Xanthos
    Intensive Care Medicine Experimental.2022;[Epub]     CrossRef
  • Assessment of Dynamic Changes in Stressed Volume and Venous Return during Hyperdynamic Septic Shock
    Athanasios Chalkias, Eleni Laou, Nikolaos Papagiannakis, Vaios Spyropoulos, Evaggelia Kouskouni, Kassiani Theodoraki, Theodoros Xanthos
    Journal of Personalized Medicine.2022; 12(5): 724.     CrossRef
  • A Critical Appraisal of the Effects of Anesthetics on Immune-system Modulation in Critically Ill Patients With COVID-19
    Athanasios Chalkias, Erin F. Barreto, Eleni Laou, Konstantina Kolonia, Marc H. Scheetz, Konstantinos Gourgoulianis, Ioannis Pantazopoulos, Theodoros Xanthos
    Clinical Therapeutics.2021; 43(3): e57.     CrossRef
  • Resuscitative Effect of Centhaquine (Lyfaquin®) in Hypovolemic Shock Patients: A Randomized, Multicentric, Controlled Trial
    Anil Gulati, Dinesh Jain, Nilesh Radheshyam Agrawal, Prashant Rahate, Rajat Choudhuri, Soumen Das, Deba Prasad Dhibar, Madhav Prabhu, Sameer Haveri, Rohit Agarwal, Manish S. Lavhale
    Advances in Therapy.2021; 38(6): 3223.     CrossRef
  • A Multicentric, Randomized, Controlled Phase III Study of Centhaquine (Lyfaquin®) as a Resuscitative Agent in Hypovolemic Shock Patients
    Anil Gulati, Rajat Choudhuri, Ajay Gupta, Saurabh Singh, S. K. Noushad Ali, Gursaran Kaur Sidhu, Parvez David Haque, Prashant Rahate, Aditya R. Bothra, Gyan P. Singh, Sanjiv Maheshwari, Deepak Jeswani, Sameer Haveri, Apurva Agarwal, Nilesh Radheshyam Agra
    Drugs.2021; 81(9): 1079.     CrossRef
Trauma
Inclusion of lactate level measured upon emergency room arrival in trauma outcome prediction models improves mortality prediction: a retrospective, single-center study
Jonghwan Moon, Kyungjin Hwang, Dukyong Yoon, Kyoungwon Jung
Acute Crit Care. 2020;35(2):102-109.   Published online May 31, 2020
DOI: https://doi.org/10.4266/acc.2019.00780
  • 4,989 View
  • 161 Download
  • 2 Web of Science
  • 3 Crossref
AbstractAbstract PDF
Background
This study aimed to develop a model for predicting trauma outcomes by adding arterial lactate levels measured upon emergency room (ER) arrival to existing trauma injury severity scoring systems.
Methods
We examined blunt trauma cases that were admitted to our hospital during 2010– 2014. Eligibility criteria were cases with an Injury Severity Score of ≥9, complete Trauma and Injury Severity Score (TRISS) variable data, and lactate levels that were assessed upon ER arrival. Survivor and non-survivor groups were compared and lactate-based prediction models were generated using logistic regression. We compared the predictive performances of traditional prediction models (Revised Trauma Score [RTS] and TRISS) and lactate-based models using the area under the curve (AUC) of receiver operating characteristic curves.
Results
We included 829 patients, and the in-hospital mortality rate among these patients was 21.6%. The model that used lactate levels and age provided a significantly better AUC value than the RTS model. The model with lactate added to the TRISS variables provided the highest Youden J statistic, with 86.0% sensitivity and 70.8% specificity at a cutoff value of 0.15, as well as the highest predictive value, with a significantly higher AUC than the TRISS.
Conclusions
These findings indicate that lactate testing upon ER arrival may help supplement or replace traditional physiological parameters to predict mortality outcomes among Korean trauma patients. Adding lactate levels also appears to improve the predictive abilities of existing trauma outcome prediction models.

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  • Observational Analysis of Point-of-Care Lactate Plus™ Meter in Preclinical Trauma Models
    Catharina Gaeth, Jamila Duarte, Alvaro Rodriguez, Amber Powers, Randolph Stone
    Diagnostics.2024; 14(23): 2641.     CrossRef
  • Plasma interleukin responses as predictors of outcome stratification in patients after major trauma: a prospective observational two centre study
    Matthew Allan Jones, James Hanison, Renata Apreutesei, Basmah Allarakia, Sara Namvar, Deepa Shruthi Ramaswamy, Daniel Horner, Lucy Smyth, Richard Body, Malachy Columb, Mahesan Nirmalan, Niroshini Nirmalan
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Admission Lactate and Base Deficit in Predicting Outcomes of Pediatric Trauma
    Yo Huh, Yura Ko, Kyungjin Hwang, Kyoungwon Jung, Yoon-ho Cha, Yoo Jin Choi, Jisook Lee, Jung Heon Kim
    Shock.2021; 55(4): 495.     CrossRef
Brief Communication
Intensivist/Policy
Experience of augmenting critical care capacity in Daegu during COVID-19 incident in South Korea
Je Hyeong Kim, Suk-Kyung Hong, Younghwan Kim, Ho Geol Ryu, Chi-Min Park, Young Seok Lee, Sung Jin Hong
Acute Crit Care. 2020;35(2):110-114.   Published online May 31, 2020
DOI: https://doi.org/10.4266/acc.2020.00275
  • 6,788 View
  • 164 Download
  • 7 Web of Science
  • 8 Crossref
PDF

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    Younghwan Kim, Seok Hwa Youn
    Journal of Acute Care Surgery.2023; 13(2): 43.     CrossRef
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    Sang Wook Lee, You Kyoung Shin, Jeong-Min Lee, Geun Hee Seol
    Frontiers in Psychiatry.2023;[Epub]     CrossRef
  • What happened during the period from senior medical students’ withdrawal of their applications to take the Korean Medical Licensing Examination in August 2020 to their taking the licensing examination in February 2021
    Sun Huh
    Journal of Educational Evaluation for Health Professions.2022; 19: 3.     CrossRef
  • Comparison of clinical characteristics and hospital mortality in critically ill patients without COVID-19 before and during the COVID-19 pandemic: a multicenter, retrospective, propensity score-matched study
    Sua Kim, Hangseok Choi, Jae Kyeom Sim, Won Jai Jung, Young Seok Lee, Je Hyeong Kim
    Annals of Intensive Care.2022;[Epub]     CrossRef
  • Correlation Between Third Dose of COVID-19 Vaccines and Regional Case Fatality Rates During the Omicron Wave in Korea
    Youngook Jang, In Joong Kim, Sung-Sil Moon, Sun Bean Kim, Jacob Lee
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
  • Socioeconomic disparity and the risk of contracting COVID-19 in South Korea: an NHIS-COVID-19 database cohort study
    Tak Kyu Oh, Jae-Wook Choi, In-Ae Song
    BMC Public Health.2021;[Epub]     CrossRef
  • Association of Intensive Care Unit Patient Load and Demand With Mortality Rates in US Department of Veterans Affairs Hospitals During the COVID-19 Pandemic
    Dawn M. Bravata, Anthony J. Perkins, Laura J. Myers, Greg Arling, Ying Zhang, Alan J. Zillich, Lindsey Reese, Andrew Dysangco, Rajiv Agarwal, Jennifer Myers, Charles Austin, Ali Sexson, Samuel J. Leonard, Sharmistha Dev, Salomeh Keyhani
    JAMA Network Open.2021; 4(1): e2034266.     CrossRef
  • Impact of staffing model conversion from a mandatory critical care consultation model to a closed unit model in the medical intensive care unit
    Sung Jun Ko, Jaeyoung Cho, Sun Mi Choi, Young Sik Park, Chang-Hoon Lee, Chul-Gyu Yoo, Jinwoo Lee, Sang-Min Lee, Robert Jeenchen Chen
    PLOS ONE.2021; 16(10): e0259092.     CrossRef
Editorial
Pediatric
Intensivists in the pediatric intensive care unit: conductors for better operational efficiency
June Dong Park
Acute Crit Care. 2020;35(2):115-116.   Published online May 31, 2020
DOI: https://doi.org/10.4266/acc.2020.00276
  • 3,928 View
  • 111 Download
PDF
Case Reports
Pulmonary
Right ventricular assist device with an oxygenator using extracorporeal membrane oxygenation as a bridge to lung transplantation in a patient with severe respiratory failure and right heart decompensation
Dong Kyu Oh, Tae Sun Shim, Kyung-Wook Jo, Seung-Il Park, Dong Kwan Kim, Sehoon Choi, Geun Dong Lee, Sung-Ho Jung, Pil-Je Kang, Sang-Bum Hong
Acute Crit Care. 2020;35(2):117-121.   Published online April 8, 2019
DOI: https://doi.org/10.4266/acc.2018.00416
  • 10,609 View
  • 288 Download
  • 21 Web of Science
  • 22 Crossref
AbstractAbstract PDF
Right heart decompensation is a fatal complication in patients with respiratory failure, particularly in those transitioned to lung transplantation using veno-venous extracorporeal membrane oxygenation (V-V ECMO). In these patients, veno-arterial (V-A ECMO) or veno-arterialvenous extracorporeal membrane oxygenation (V-AV ECMO) is used to support both cardiac and respiratory function. However, these processes may increase the risk of device-related complications such as bleeding, thromboembolism, and limb ischemia. In the present case, a 64-year-old male patient with idiopathic pulmonary fibrosis developed respiratory failure and commenced treatment with V-V ECMO as a bridge to lung transplantation. Unfortunately, the patient developed right heart decompensation and required both cardiac and respiratory support during treatment with V-V ECMO. Instead of adding arterial cannulation, he was switched to a novel configuration, a right ventricular assist device with an oxygenator (Oxy- RVAD) using ECMO, with drainage cannulation from the femoral vein and return cannulation to the main pulmonary artery. The patient was successfully bridged to lung transplantation without serious complications after 10 days of Oxy-RVAD support. To the best of our knowledge, this is an extreme rare and challenging case of Oxy-RVAD using ECMO in a patient successfully bridged to lung transplantation.

Citations

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  • The Role of Palliative Care in Cardiovascular Disease
    John Arthur McClung, William H. Frishman, Wilbert S. Aronow
    Cardiology in Review.2024;[Epub]     CrossRef
  • Percutaneous Venopulmonary Extracorporeal Membrane Oxygenation as Bridge to Lung Transplantation
    Asad Ali Usman, Audrey Elizabeth Spelde, Wasim Lutfi, Jacob T. Gutsche, William J. Vernick, Omar Toubat, Salim E. Olia, Edward Cantu, Andrew Courtright, Maria M. Crespo, Joshua Diamond, Mauer Biscotti, Christian A. Bermudez
    ASAIO Journal.2024; 70(9): 758.     CrossRef
  • Right Ventricular Assist Device With an Oxygenator for the Management of Combined Right Ventricular and Respiratory Failure: A Systematic Review
    Juliette Beaulieu, Christine Vu, Sanjog Kalra, Hamza Ouazani Chahdi, Julie Cousineau, Alexis Matteau, Samer Mansour, E. Marc Jolicoeur, Sabrina Jacques, Bénédicte Nauche, Renata Podbielski, Pasquale Ferraro, Charles Poirier, Brian J. Potter
    Canadian Journal of Cardiology.2024; 40(9): 1732.     CrossRef
  • Percutaneous OxyRVAD in a Patient with Severe Respiratory Failure and Right Heart Failure: A Case Report
    Ga Young Yoo, June Lee, Seok Beom Hong, Do Yeon Kim
    Journal of Chest Surgery.2024; 57(3): 319.     CrossRef
  • Central Venopulmonary Extracorporeal Membrane Oxygenation: Background and Standardized Nomenclature
    J. Michael Brewer, Roberto Lorusso, L. Mikael Broman, Steven A. Conrad, Justyna Swol, Marc O. Maybauer
    ASAIO Journal.2024; 70(9): e123.     CrossRef
  • Outcomes of Lung Transplantation in Patients With Right Ventricular Dysfunction: A Single-Center Retrospective Analysis Comparing ECMO Configurations in a Bridge-to-Transplant Setting
    Su Yeon Lee, Jee Hwan Ahn, Ho Cheol Kim, Tae Sun Shim, Pil-Je Kang, Geun Dong Lee, Se Hoon Choi, Sung-Ho Jung, Seung-Il Park, Sang-Bum Hong
    Transplant International.2024;[Epub]     CrossRef
  • Venopulmonary extracorporeal membrane oxygenation for right ventricular support as a bridge to lung transplantation: A narrative review
    Phan Quang Thuan, Nguyen Hoai Nam, Nguyen Hoang Dinh
    SAGE Open Medicine.2024;[Epub]     CrossRef
  • Early Mobilization for a Patient With a Right Ventricular Assist Device With an Oxygenator
    Sheena MacFarlane, Vanessa Lee, Adrienne H. Simonds, Samantha Alvarez, Samantha Carty, Kevin H. Ewers, Victoria R. Kelly, Parker Linden, Amanda L. Moskal
    Journal of Acute Care Physical Therapy.2023; 14(1): 45.     CrossRef
  • A 35-month-old boy who ingested laundry detergent pods and underwent veno-pulmonary extracorporeal membrane oxygenation support
    Hye-ji Han, Bongjin Lee, Won Jin Jang, Ji Won Lee, Jin Hee Kim, Sungkyu Cho, June Dong Park
    Pediatric Emergency Medicine Journal.2023; 10(4): 175.     CrossRef
  • Right Ventricular Assist Device With Extracorporeal Membrane Oxygenation for Bridging Right Ventricular Heart Failure to Lung Transplantation: A Single-Center Case Series and Literature Review
    Jae Guk Lee, Chuiyong Pak, Dong Kyu Oh, Ho Cheol Kim, Pil-Je Kang, Geun Dong Lee, Se Hoon Choi, Sung-Ho Jung, Sang-Bum Hong
    Journal of Cardiothoracic and Vascular Anesthesia.2022; 36(6): 1686.     CrossRef
  • Advanced Circulatory Support and Lung Transplantation in Pulmonary Hypertension
    Marie M. Budev, James J. Yun
    Cardiology Clinics.2022; 40(1): 129.     CrossRef
  • A Review of Pulmonary Arterial Hypertension Treatment in Extracorporeal Membrane Oxygenation: A Case Series of Adult Patients
    Heather Torbic, Benjamin Hohlfelder, Sudhir Krishnan, Adriano R. Tonelli
    Journal of Cardiovascular Pharmacology and Therapeutics.2022;[Epub]     CrossRef
  • A Comprehensive Review of Mechanical Circulatory Support Devices
    Varunsiri Atti, Mahesh Anantha Narayanan, Brijesh Patel, Sudarshan Balla, Aleem Siddique, Scott Lundgren, Poonam Velagapudi
    Heart International.2022; 16(1): 37.     CrossRef
  • Comprehensive Monitoring in Patients With Dual Lumen Right Atrium to Pulmonary Artery Right Ventricular Assist Device
    Asad A. Usman, Audrey E. Spelde, Michael Ibrahim, Marisa Cevasco, Christian Bermudez, Emily MacKay, Sameer Khandhar, Wilson Szeto, William Vernick, Jacob Gutsche
    ASAIO Journal.2022; 68(12): 1461.     CrossRef
  • Percutaneous Pulmonary Artery Cannulation to Treat Acute Secondary Right Heart Failure While on Veno-venous Extracorporeal Membrane Oxygenation
    Kelly M. Ivins-O’Keefe, Michael S. Cahill, Arthur R. Mielke, Michal J. Sobieszczyk, Valerie G. Sams, Phillip E. Mason, Matthew D. Read
    ASAIO Journal.2022; 68(12): 1483.     CrossRef
  • The ProtekDuo for percutaneous V-P and V-VP ECMO in patients with COVID-19 ARDS
    Ahmed M El Banayosy, Aly El Banayosy, Joseph M Brewer, Mircea R Mihu, Jaclyn M Chidester, Laura V Swant, Robert S Schoaps, Ammar Sharif, Marc O Maybauer
    The International Journal of Artificial Organs.2022; 45(12): 1006.     CrossRef
  • Critical Care Management of the Patient with Pulmonary Hypertension
    Christopher J. Mullin, Corey E. Ventetuolo
    Clinics in Chest Medicine.2021; 42(1): 155.     CrossRef
  • Successful Lung Transplantation After 213 Days of Extracorporeal Life Support: Role of Oxygenator-Right Ventricular Assist Device
    Jae Kyeom Sim, Kyeongman Jeon, Gee Young Suh, Suryeun Chung, Yang Hyun Cho
    ASAIO Journal.2021; 67(7): e127.     CrossRef
  • Oxy-right Ventricular Assist Device for Bridging of Right Heart Failure to Lung Transplantation
    Sung Kwang Lee, Do Hyung Kim, Woo Hyun Cho, Hye Ju Yeo
    Transplantation.2021; 105(7): 1610.     CrossRef
  • Interventional and Surgical Treatments for Pulmonary Arterial Hypertension
    Tomasz Stącel, Magdalena Latos, Maciej Urlik, Mirosław Nęcki, Remigiusz Antończyk, Tomasz Hrapkowicz, Marcin Kurzyna, Marek Ochman
    Journal of Clinical Medicine.2021; 10(15): 3326.     CrossRef
  • Intraoperative Management of Adult Patients on Extracorporeal Membrane Oxygenation: an Expert Consensus Statement From the Society of Cardiovascular Anesthesiologists—Part I, Technical Aspects of Extracorporeal Membrane Oxygenation
    Michael A. Mazzeffi, Vidya K. Rao, Jeffrey Dodd-o, Jose Mauricio Del Rio, Antonio Hernandez, Mabel Chung, Amit Bardia, Rebecca M. Bauer, Joseph S. Meltzer, Sree Satyapriya, Raymond Rector, James G. Ramsay, Jacob Gutsche
    Journal of Cardiothoracic and Vascular Anesthesia.2021; 35(12): 3496.     CrossRef
  • Intraoperative Management of Adult Patients on Extracorporeal Membrane Oxygenation: An Expert Consensus Statement From the Society of Cardiovascular Anesthesiologists—Part I, Technical Aspects of Extracorporeal Membrane Oxygenation
    Michael A. Mazzeffi, Vidya K. Rao, Jeffrey Dodd-o, Jose Mauricio Del Rio, Antonio Hernandez, Mabel Chung, Amit Bardia, Rebecca M. Bauer, Joseph S. Meltzer, Sree Satyapriya, Raymond Rector, James G. Ramsay, Jacob Gutsche
    Anesthesia & Analgesia.2021;[Epub]     CrossRef
Pulmonary
Lung injury associated with inhalation of effective microorganism blends
Jee-min Kim, Yoon Jin Kwak, Ho Il Yoon
Acute Crit Care. 2020;35(2):122-126.   Published online April 8, 2019
DOI: https://doi.org/10.4266/acc.2018.00332
  • 10,506 View
  • 127 Download
AbstractAbstract PDF
Since 2009, effective microorganisms (EMs) have been supplied by the local government to the citizens of Seongnam, Korea, for various environment-protective uses including manufacturing detergents, cosmetics and humidifier disinfectants. A 68-year-old man who had placed an EM blends into a humidifier for inhalation visited the emergency room with complaints of fever and dyspnea. He was in a shock state with hypoxia. Chest computed tomography revealed diffuse ground-glass opacities that were dominant in the bilateral upper lobes. Fiberoptic bronchoscopy with bronchoalveolar lavage and transbronchial lung biopsy was performed. Bronchoalveolar lavage fluid analysis and biopsy findings were consistent with alveolar hemorrhage. All microbiological and virological test results were negative. His symptoms and radiographic opacities had improved markedly after several days of conservative care, and he was discharged healthy after 1 week of hospital stay.
Letter to the Editor
Pulmonary
Is percutaneous dilatational tracheostomy with bronchoscopic guidance better than without?
Jinsun Chang, Hong-Joon Shin, Yong-Soo Kwon, Yu-Il Kim, Sung-Chul Lim, Tae-Ok Kim
Acute Crit Care. 2020;35(2):127-129.   Published online May 31, 2020
DOI: https://doi.org/10.4266/acc.2020.00101
  • 6,005 View
  • 108 Download
PDF

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