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1 "Yun Young Park"
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Original Article
Basic science and research
Anti-inflammatory Role of Mesenchymal Stem Cells in an Acute Lung Injury Mouse Model
Jin Won Huh, Won Young Kim, Yun Young Park, Chae-Man Lim, Younsuck Koh, Mi-Jung Kim, Sang-Bum Hong
Acute Crit Care. 2018;33(3):154-161.   Published online August 31, 2018
DOI: https://doi.org/10.4266/acc.2018.00619
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  • 9 Web of Science
  • 8 Crossref
AbstractAbstract PDFSupplementary Material
Background
Mesenchymal stem cells (MSCs) attenuate injury in various lung injury models through paracrine effects. We hypothesized that intratracheal transplantation of allogenic MSCs could attenuate lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice, mediated by anti-inflammatory responses.
Methods
Six-week-old male mice were randomized to either the control or the ALI group. ALI was induced by intratracheal LPS instillation. Four hours after LPS instillation, MSCs or phosphate-buffered saline was randomly intratracheally administered. Neutrophil count and protein concentration in bronchoalveolar lavage fluid (BALF); lung histology; levels of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and macrophage inflammatory protein-2; and the expression of proliferation cell nuclear antigen (PCNA), caspase-3, and caspase-9 were evaluated at 48 hours after injury.
Results
Treatment with MSCs attenuated lung injury in ALI mice by decreasing protein level and neutrophil recruitment into the BALF and improving the histologic change. MSCs also decreased the protein levels of proinflammatory cytokines including IL-1β, IL-6, and TNF-α, but had little effect on the protein expression of PCNA, caspase-3, and caspase-9.
Conclusions
Intratracheal injection of bone marrow-derived allogenic MSCs attenuates LPSinduced ALI via immunomodulatory effects.

Citations

Citations to this article as recorded by  
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    Journal of Personalized Medicine.2024; 14(1): 121.     CrossRef
  • Cyclic Phytosphingosine-1-Phosphate Primed Mesenchymal Stem Cells Ameliorate LPS-Induced Acute Lung Injury in Mice
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    International Journal of Stem Cells.2023; 16(2): 191.     CrossRef
  • Mesenchymal stem cells and their derived exosomes to combat Covid–19
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    Reviews in Medical Virology.2022;[Epub]     CrossRef
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    Journal of Cellular and Molecular Medicine.2022; 26(9): 2483.     CrossRef
  • Development of a physiomimetic model of acute respiratory distress syndrome by using ECM hydrogels and organ-on-a-chip devices
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    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Advances in mesenchymal stromal cell therapy for acute lung injury/acute respiratory distress syndrome
    Chang Liu, Kun Xiao, Lixin Xie
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • Auxiliary role of mesenchymal stem cells as regenerative medicine soldiers to attenuate inflammatory processes of severe acute respiratory infections caused by COVID-19
    Peyvand Parhizkar Roudsari, Sepideh Alavi-Moghadam, Moloud Payab, Forough Azam Sayahpour, Hamid Reza Aghayan, Parisa Goodarzi, Fereshteh Mohamadi-jahani, Bagher Larijani, Babak Arjmand
    Cell and Tissue Banking.2020; 21(3): 405.     CrossRef
  • The Role of MSC Therapy in Attenuating the Damaging Effects of the Cytokine Storm Induced by COVID-19 on the Heart and Cardiovascular System
    Georgina M. Ellison-Hughes, Liam Colley, Katie A. O'Brien, Kirsty A. Roberts, Thomas A. Agbaedeng, Mark D. Ross
    Frontiers in Cardiovascular Medicine.2020;[Epub]     CrossRef

ACC : Acute and Critical Care